Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms.

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Title: Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms.
Authors: Wu Y; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Xu P; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Moran J; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Xu CS; Janelia Research Campus, HHMI, Ashburn, VA 20147., Hayworth KJ; Janelia Research Campus, HHMI, Ashburn, VA 20147., Cao M; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Shao L; Center for Neurodevelopment and Plasticity, Wu Tsai Institute, Yale University, New Haven, CT,USA., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Hess HF; Janelia Research Campus, HHMI, Ashburn, VA 20147., Camilli P; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 29. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.06.24.733515