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Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain.

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Title: Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain.
Authors: Ayuketah A; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Meredith M; DataTecnica LLC, Washington, DC, USA., Groza C; Montreal Heart Institute, Université de Montréal, QC, Canada., Moller J; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Daida K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Catching A; DataTecnica LLC, Washington, DC, USA., Weller C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Kouam C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Paulin L; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Malik L; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Baker B; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Hu F; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bromberek S; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Jerez PA; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Department of Biology, Johns Hopkins University, Baltimore, MD, USA.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA., Paquette K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Izydorczyk M; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Gu B; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Chaisson MJP; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Middlehurst B; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Bubb VJ; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Quinn JP; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Price E; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH., Singleton AB; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Jain M; Department of Bioengineering, Department of Physics, Northeastern University, Boston, MA, USA., Blauwendraat C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Nalls M; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Cookson MR; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Reed X; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sedlazeck FJ; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA., Goubert C; R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA., Billingsley KJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain.
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  Data: <searchLink fieldCode="AU" term="%22Ayuketah+A%22">Ayuketah A</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Meredith+M%22">Meredith M</searchLink>; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Groza+C%22">Groza C</searchLink>; Montreal Heart Institute, Université de Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Moller+J%22">Moller J</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Daida+K%22">Daida K</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Catching+A%22">Catching A</searchLink>; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Weller+C%22">Weller C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Kouam+C%22">Kouam C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Paulin+L%22">Paulin L</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Malik+L%22">Malik L</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baker+B%22">Baker B</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bromberek+S%22">Bromberek S</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jerez+PA%22">Jerez PA</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Department of Biology, Johns Hopkins University, Baltimore, MD, USA.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Paquette+K%22">Paquette K</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Izydorczyk+M%22">Izydorczyk M</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gu+B%22">Gu B</searchLink>; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chaisson+MJP%22">Chaisson MJP</searchLink>; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Middlehurst+B%22">Middlehurst B</searchLink>; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Bubb+VJ%22">Bubb VJ</searchLink>; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Quinn+JP%22">Quinn JP</searchLink>; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Price+E%22">Price E</searchLink>; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jain+M%22">Jain M</searchLink>; Department of Bioengineering, Department of Physics, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nalls+M%22">Nalls M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Cookson+MR%22">Cookson MR</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reed+X%22">Reed X</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sedlazeck+FJ%22">Sedlazeck FJ</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA.<br /><searchLink fieldCode="AU" term="%22Goubert+C%22">Goubert C</searchLink>; R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Billingsley+KJ%22">Billingsley KJ</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
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