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CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.

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Title: CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.
Authors: Moore JC; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA., Takeuchi H; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA., Nguyen C; Complex Carbohydrate Research Center, University of Georgia, Athens, GA., Huang C; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA., Chapla D; Complex Carbohydrate Research Center, University of Georgia, Athens, GA., Basu A; Complex Carbohydrate Research Center, University of Georgia, Athens, GA., Wang Z; Glycan Therapeutics Corp, Raleigh, NC., Liu J; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Moremen KW; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA., Weiss RJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.
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  Data: <searchLink fieldCode="AU" term="%22Moore+JC%22">Moore JC</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Takeuchi+H%22">Takeuchi H</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Nguyen+C%22">Nguyen C</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Chapla+D%22">Chapla D</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Basu+A%22">Basu A</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Glycan Therapeutics Corp, Raleigh, NC.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Moremen+KW%22">Moremen KW</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.<br /><searchLink fieldCode="AU" term="%22Weiss+RJ%22">Weiss RJ</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.06.29.735380
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              Text: 2026 Jun 30
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