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Multi-ancestry modeling improves fine-mapping resolution, protein prediction, and discovery for proteome-wide association studies.

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Title: Multi-ancestry modeling improves fine-mapping resolution, protein prediction, and discovery for proteome-wide association studies.
Authors: Krueger CJ; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA., Fischer M; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA., Rizwan T; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA., Kumar MM; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA., Bhargava S; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA., Gerszten R; Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Perera MA; Department of Pharmacology, Northwestern University, Chicago IL, 60611, USA., Hu X; Department of Genome Sciences, University of Virginia, Charlottesville, VA, 22908, USA., Manichaikul A; Department of Genome Sciences, University of Virginia, Charlottesville, VA, 22908, USA., Im HK; Section of Genetic Medicine, The University of Chicago, Chicago, IL, 60637, USA., Wheeler HE; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.; Department of Biology, Loyola University Chicago, Chicago, IL, 60660, USA.
Corporate Authors: NHLBI TOPMed Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jul 01. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Krueger+CJ%22">Krueger CJ</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+M%22">Fischer M</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.<br /><searchLink fieldCode="AU" term="%22Rizwan+T%22">Rizwan T</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+MM%22">Kumar MM</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.<br /><searchLink fieldCode="AU" term="%22Bhargava+S%22">Bhargava S</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.<br /><searchLink fieldCode="AU" term="%22Gerszten+R%22">Gerszten R</searchLink>; Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+KD%22">Taylor KD</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.<br /><searchLink fieldCode="AU" term="%22Cho+MH%22">Cho MH</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.<br /><searchLink fieldCode="AU" term="%22Perera+MA%22">Perera MA</searchLink>; Department of Pharmacology, Northwestern University, Chicago IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA, 22908, USA.<br /><searchLink fieldCode="AU" term="%22Manichaikul+A%22">Manichaikul A</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA, 22908, USA.<br /><searchLink fieldCode="AU" term="%22Im+HK%22">Im HK</searchLink>; Section of Genetic Medicine, The University of Chicago, Chicago, IL, 60637, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+HE%22">Wheeler HE</searchLink>; Program in Bioinformatics, Loyola University Chicago, Chicago, IL, 60660, USA.; Department of Biology, Loyola University Chicago, Chicago, IL, 60660, USA.
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              Text: 2026 Jul 01
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