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A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence.

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Title: A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence.
Authors: Kaneda G; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA., Wechsler JT; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA., Chavez M; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA., Sheyn J; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA., Cheema K; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA., Shen C; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA., Rigo De Righi D; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA., Wang L; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA., Hsu YC; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA., Avalos P; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA., Xie Y; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA., Tawackoli W; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA.; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Orthopaedics Cedars-Sinai Medical Center Los Angeles California USA.; Department of Surgery Cedars-Sinai Medical Center Los Angeles California USA., Floyd C; Department of Emergency Medicine Emory University Atlanta Georgia USA., Li D; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA., Sheyn D; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Orthopaedics Cedars-Sinai Medical Center Los Angeles California USA.; Department of Surgery Cedars-Sinai Medical Center Los Angeles California USA.
Source: JOR spine [JOR Spine] 2026 Jul 09; Vol. 9 (3), pp. e70200. Date of Electronic Publication: 2026 Jul 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Periodicals, Inc Country of Publication: United States NLM ID: 101722350 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-1143 (Electronic) Linking ISSN: 25721143 NLM ISO Abbreviation: JOR Spine Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence.
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  Data: <searchLink fieldCode="AU" term="%22Kaneda+G%22">Kaneda G</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Wechsler+JT%22">Wechsler JT</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Chavez+M%22">Chavez M</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Sheyn+J%22">Sheyn J</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Cheema+K%22">Cheema K</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Shen+C%22">Shen C</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Rigo+De+Righi+D%22">Rigo De Righi D</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Hsu+YC%22">Hsu YC</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Avalos+P%22">Avalos P</searchLink>; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Tawackoli+W%22">Tawackoli W</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA.; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Orthopaedics Cedars-Sinai Medical Center Los Angeles California USA.; Department of Surgery Cedars-Sinai Medical Center Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Floyd+C%22">Floyd C</searchLink>; Department of Emergency Medicine Emory University Atlanta Georgia USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Bioengineering University of California Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Sheyn+D%22">Sheyn D</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center Los Angeles California USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Biomedical Sciences Cedars-Sinai Medical Center, Cedars-Sinai Medical Center Los Angeles California USA.; Department of Orthopaedics Cedars-Sinai Medical Center Los Angeles California USA.; Department of Surgery Cedars-Sinai Medical Center Los Angeles California USA.
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