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Early Versus Late(r) Administration of Intrapleural Fibrinolytic Therapy in Children with Empyema: A Systematic Review and Meta-Analysis.

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Title: Early Versus Late(r) Administration of Intrapleural Fibrinolytic Therapy in Children with Empyema: A Systematic Review and Meta-Analysis.
Authors: Kaur D; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Kumar K; Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India., Mishra P; Department of Pediatrics, Srirama Chandra Bhanj Medical College, Cuttack, Odisha, India.; Department of Pediatrics, SVP PG Institute of Paediatrics, Cuttack, Odisha, India., Santuka N; Department of Pediatrics, Dharanidhar Medical College and Hospital, Keonjhar, Odisha, India., Tayal A; Department of Pediatrics, Manipal Hospitals, Goa, India., Pradhan P; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Mathew JL; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; DHR Technical Resource Hub for Evidence Based Guidelines, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.
Source: Indian pediatrics [Indian Pediatr] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article; Review
Journal Info: Publisher: Indian Pediatrics Country of Publication: India NLM ID: 2985062R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0974-7559 (Electronic) Linking ISSN: 00196061 NLM ISO Abbreviation: Indian Pediatr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early Versus Late(r) Administration of Intrapleural Fibrinolytic Therapy in Children with Empyema: A Systematic Review and Meta-Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Kaur+D%22">Kaur D</searchLink>; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.<br /><searchLink fieldCode="AU" term="%22Kumar+K%22">Kumar K</searchLink>; Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Mishra+P%22">Mishra P</searchLink>; Department of Pediatrics, Srirama Chandra Bhanj Medical College, Cuttack, Odisha, India.; Department of Pediatrics, SVP PG Institute of Paediatrics, Cuttack, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Santuka+N%22">Santuka N</searchLink>; Department of Pediatrics, Dharanidhar Medical College and Hospital, Keonjhar, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Tayal+A%22">Tayal A</searchLink>; Department of Pediatrics, Manipal Hospitals, Goa, India.<br /><searchLink fieldCode="AU" term="%22Pradhan+P%22">Pradhan P</searchLink>; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.<br /><searchLink fieldCode="AU" term="%22Mathew+JL%22">Mathew JL</searchLink>; Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; Pediatric Empyema Guideline Project, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.; DHR Technical Resource Hub for Evidence Based Guidelines, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. dr.joseph.l.mathew@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%222985062R%22">Indian pediatrics</searchLink> [Indian Pediatr] 2026 Jul 10. <i>Date of Electronic Publication: </i>2026 Jul 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Indian+Pediatrics%22">Indian Pediatrics </searchLink><i>Country of Publication: </i>India <i>NLM ID: </i>2985062R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>0974-7559 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200196061%22">00196061 </searchLink><i>NLM ISO Abbreviation: </i>Indian Pediatr <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s13312-026-00395-4
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              Text: 2026 Jul 10
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