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Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.

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Title: Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.
Authors: Kappelhoff S; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Holtmannspötter M; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Schaefer SL; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany., Margheritis EG; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Asik ÖD; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Gehle N; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Veit H; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Danial JSH; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Franzkoch R; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Strauss S; Faculty of Physics and Center for Nanoscience, Ludwig Maximilian University, Munich, Germany.; Max Planck Institute of Biochemistry, Martinsried, Germany., Alvelid J; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden., Koerfer A; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Institute for Applied Optics and Biophysics, Friedrich Schiller University Jena, Jena, Germany., Eggeling C; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Institute for Applied Optics and Biophysics, Friedrich Schiller University Jena, Jena, Germany., Psathaki OE; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Jungmann R; Faculty of Physics and Center for Nanoscience, Ludwig Maximilian University, Munich, Germany.; Max Planck Institute of Biochemistry, Martinsried, Germany., Kurre R; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany., Piehler J; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany., Cosentino K; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.
Source: Science advances [Sci Adv] 2026 Jul 10; Vol. 12 (28), pp. eaee4587. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Kappelhoff+S%22">Kappelhoff S</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Holtmannspötter+M%22">Holtmannspötter M</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Schaefer+SL%22">Schaefer SL</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Margheritis+EG%22">Margheritis EG</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Asik+ÖD%22">Asik ÖD</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Gehle+N%22">Gehle N</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Veit+H%22">Veit H</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Danial+JSH%22">Danial JSH</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Franzkoch+R%22">Franzkoch R</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Strauss+S%22">Strauss S</searchLink>; Faculty of Physics and Center for Nanoscience, Ludwig Maximilian University, Munich, Germany.; Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Alvelid+J%22">Alvelid J</searchLink>; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Koerfer+A%22">Koerfer A</searchLink>; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Institute for Applied Optics and Biophysics, Friedrich Schiller University Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Eggeling+C%22">Eggeling C</searchLink>; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.; Institute for Applied Optics and Biophysics, Friedrich Schiller University Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Psathaki+OE%22">Psathaki OE</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Jungmann+R%22">Jungmann R</searchLink>; Faculty of Physics and Center for Nanoscience, Ludwig Maximilian University, Munich, Germany.; Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Kurre+R%22">Kurre R</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Hummer+G%22">Hummer G</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Piehler+J%22">Piehler J</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.<br /><searchLink fieldCode="AU" term="%22Cosentino+K%22">Cosentino K</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs), Osnabrück University, Osnabrück, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Jul 10; Vol. 12 (28), pp. eaee4587. <i>Date of Electronic Publication: </i>2026 Jul 10.
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