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Piezo2+ mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus.

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Title: Piezo2+ mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus.
Authors: Wang Z; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Modave E; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Van Remoortel S; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Pajk N; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Vanden Berghe P; Laboratory for Enteric Neuroscience (LENS), Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Chen Y; Laboratory of Mucosal Immunology, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Vandeput M; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Appeltans I; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Quan R; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Matteoli G; Laboratory of Mucosal Immunology, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Stakenborg N; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Boeckxstaens G; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium guy.boeckxstaens@kuleuven.be.
Source: Gut [Gut] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Piezo2<superscript>+</superscript> mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Modave+E%22">Modave E</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Remoortel+S%22">Van Remoortel S</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Pajk+N%22">Pajk N</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanden+Berghe+P%22">Vanden Berghe P</searchLink>; Laboratory for Enteric Neuroscience (LENS), Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Laboratory of Mucosal Immunology, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandeput+M%22">Vandeput M</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Appeltans+I%22">Appeltans I</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Quan+R%22">Quan R</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Matteoli+G%22">Matteoli G</searchLink>; Laboratory of Mucosal Immunology, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Stakenborg+N%22">Stakenborg N</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Boeckxstaens+G%22">Boeckxstaens G</searchLink>; Center of Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium guy.boeckxstaens@kuleuven.be.
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      – Type: doi
        Value: 10.1136/gutjnl-2025-336369
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        Text: English
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      – TitleFull: Piezo2+ mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus.
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            – D: 10
              M: 07
              Text: 2026 Jul 10
              Type: published
              Y: 2026
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