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Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.

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Title: Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.
Authors: Burke BI; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Valentino TR; Buck Institute for Research on Aging, Novato, CA, USA., Ismaeel A; Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., El-Amouri SS; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Goh J; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Scott LN; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Walton BJ; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Joshi JK; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Wood CR; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA., Burrows-Franco A; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Mass Spectrometry and Proteomics Core, University of Kentucky, Lexington, KY, USA., May JB; Department of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA., Johnson LA; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Flythe MD; USDA Agriculture Research Service, Forage-Animal Production Research Unit, University of Kentucky, Lexington, KY, USA.; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA., Wen Y; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu., McCarthy JJ; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA. jjmcca2@uky.edu.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA. jjmcca2@uky.edu.
Source: Nature communications [Nat Commun] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.
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  Data: <searchLink fieldCode="AU" term="%22Burke+BI%22">Burke BI</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Valentino+TR%22">Valentino TR</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ismaeel+A%22">Ismaeel A</searchLink>; Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.<br /><searchLink fieldCode="AU" term="%22El-Amouri+SS%22">El-Amouri SS</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Goh+J%22">Goh J</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LN%22">Scott LN</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Walton+BJ%22">Walton BJ</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+JK%22">Joshi JK</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Wood+CR%22">Wood CR</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Burrows-Franco+A%22">Burrows-Franco A</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Mass Spectrometry and Proteomics Core, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22May+JB%22">May JB</searchLink>; Department of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+LA%22">Johnson LA</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Flythe+MD%22">Flythe MD</searchLink>; USDA Agriculture Research Service, Forage-Animal Production Research Unit, University of Kentucky, Lexington, KY, USA.; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.<br /><searchLink fieldCode="AU" term="%22McCarthy+JJ%22">McCarthy JJ</searchLink>; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA. jjmcca2@uky.edu.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA. jjmcca2@uky.edu.
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