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S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers.

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Title: S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers.
Authors: Bhatt R; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Ong SE; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Erkes DA; Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Leung KMX; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Kinase K; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Lim KY; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Bonfim-Melo A; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia., Alghamdi E; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia., Daignault-Mill S; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia., Lim Y; Centre for Cancer Biology, College of Health, Adelaide University, Adelaide, SA, Australia., Abdul Rahim NJ; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Gopalakrishnan A; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Ong XY; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Goh NLL; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Gandini A; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Proctor M; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Kumar S; Centre for Cancer Biology, College of Health, Adelaide University, Adelaide, SA, Australia., Zeng Z; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Haass NK; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia., Jones MJ; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.; School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Clarke P; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.; Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD, Australia., Aplin AE; Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Gabrielli B; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia. brianG@uq.edu.au.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bhatt+R%22">Bhatt R</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Ong+SE%22">Ong SE</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Erkes+DA%22">Erkes DA</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Leung+KMX%22">Leung KMX</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Kinase+K%22">Kinase K</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+KY%22">Lim KY</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Bonfim-Melo+A%22">Bonfim-Melo A</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Alghamdi+E%22">Alghamdi E</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Daignault-Mill+S%22">Daignault-Mill S</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+Y%22">Lim Y</searchLink>; Centre for Cancer Biology, College of Health, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Abdul+Rahim+NJ%22">Abdul Rahim NJ</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Gopalakrishnan+A%22">Gopalakrishnan A</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Ong+XY%22">Ong XY</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Goh+NLL%22">Goh NLL</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Gandini+A%22">Gandini A</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Proctor+M%22">Proctor M</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Centre for Cancer Biology, College of Health, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Zeng+Z%22">Zeng Z</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Haass+NK%22">Haass NK</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Jones+MJ%22">Jones MJ</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.; School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Clarke+P%22">Clarke P</searchLink>; Frazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, QLD, Australia.; Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Aplin+AE%22">Aplin AE</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gabrielli+B%22">Gabrielli B</searchLink>; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia. brianG@uq.edu.au.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9437445 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5403 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213509047%22">13509047 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Differ <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41418-026-01808-4
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