Premeal insulin administration lowers postprandial blood glucose and increases myocardial microvascular blood flow in people with type 1 diabetes: a randomised, crossover clinical trial.

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Title: Premeal insulin administration lowers postprandial blood glucose and increases myocardial microvascular blood flow in people with type 1 diabetes: a randomised, crossover clinical trial.
Authors: Horton WB; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA. william.horton@uvahealth.org.; University of Virginia Center for Diabetes Technology, University of Virginia School of Medicine, Charlottesville, VA, USA. william.horton@uvahealth.org., Anderson KC; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Love KM; AdventHealth Translational Research Institute, Orlando, FL, USA., Jahn LA; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Hartline LM; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Patrie JT; Division of Biostatistics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Liu J; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Solga MD; Flow Cytometry Core, University of Virginia School of Medicine, Charlottesville, VA, USA., Awan WJ; Flow Cytometry Core, University of Virginia School of Medicine, Charlottesville, VA, USA., Thakur A; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA., Schalk DL; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA., Becker MG; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA., Kuzas CE; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA., Aylor KW; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Barrett EJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Source: Diabetologia [Diabetologia] 2026 Jul 11. Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Premeal insulin administration lowers postprandial blood glucose and increases myocardial microvascular blood flow in people with type 1 diabetes: a randomised, crossover clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Horton+WB%22">Horton WB</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA. william.horton@uvahealth.org.; University of Virginia Center for Diabetes Technology, University of Virginia School of Medicine, Charlottesville, VA, USA. william.horton@uvahealth.org.<br /><searchLink fieldCode="AU" term="%22Anderson+KC%22">Anderson KC</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Love+KM%22">Love KM</searchLink>; AdventHealth Translational Research Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Jahn+LA%22">Jahn LA</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Hartline+LM%22">Hartline LM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Patrie+JT%22">Patrie JT</searchLink>; Division of Biostatistics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Solga+MD%22">Solga MD</searchLink>; Flow Cytometry Core, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Awan+WJ%22">Awan WJ</searchLink>; Flow Cytometry Core, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Thakur+A%22">Thakur A</searchLink>; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Schalk+DL%22">Schalk DL</searchLink>; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Becker+MG%22">Becker MG</searchLink>; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Kuzas+CE%22">Kuzas CE</searchLink>; Center for Human Therapeutics cGMP Facility, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Aylor+KW%22">Aylor KW</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+EJ%22">Barrett EJ</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.
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