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NME3 promotes clear cell renal cell carcinoma progression and modulates TKI response through MFN1/2-dependent mitochondrial fusion and mitophagy suppression.

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Title: NME3 promotes clear cell renal cell carcinoma progression and modulates TKI response through MFN1/2-dependent mitochondrial fusion and mitophagy suppression.
Authors: Cao S; School of Medicine, Nankai University, Tianjin, China.; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China., Chen X; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Zhang C; School of Medicine, Nankai University, Tianjin, China.; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China., Feng Y; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Shi C; School of Medicine, Nankai University, Tianjin, China.; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China., Wang J; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Xu Q; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Huang X; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Ma X; School of Medicine, Nankai University, Tianjin, China. mxin301@126.com.; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China. mxin301@126.com., Fan W; Senior Department of Urology, Chinese PLA General Hospital, Beijing, China. fan_wenmei@163.com.
Source: Oncogene [Oncogene] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5594
DOI:10.1038/s41388-026-03892-9