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Lower plasma resolvin D1 level and greater sputum eosinophilia characterize a cluster of severe asthma patients.

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Title: Lower plasma resolvin D1 level and greater sputum eosinophilia characterize a cluster of severe asthma patients.
Authors: Duvall MG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. melody.duvall@childrens.harvard.edu.; Division of Critical Care Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. melody.duvall@childrens.harvard.edu., Sun Y; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Mirzakhani H; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Pons S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Dorazio MH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Chiha T; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lu Z; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Phillips BR; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA, 17033, USA., Aronica MA; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Bleecker ER; Department of Medicine, Mayo Clinic, Scottsdale, AZ, 85259, USA., Castro M; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, 66160, USA., Comhair SA; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Denlinger LC; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA., Erzurum SC; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Fahy JV; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Hastie AT; Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Jarjour NN; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA., Khatri PK; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, 94304, USA., Meyers DA; Department of Medicine, Mayo Clinic, Scottsdale, AZ, 85259, USA., Moore WC; Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Ortega VE; Division of Respiratory Medicine, Department of Medicine, Mayo Clinic, Scottsdale, AZ, 85259, USA., Phipatanakul W; Division of Allergy, Dermatology, Rheumatology, and Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Seibold MA; Center for Genes, Environment, and Health, Department of Pediatrics, National Jewish Health, Denver, CO, 80206, USA., Sumino K; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Wenzel SE; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Woodruff PG; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Mauger DT; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA, 17033, USA., Israel E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Levy BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. blevy@bwh.harvard.edu.
Source: Respiratory research [Respir Res] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
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Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.<br /><searchLink fieldCode="AU" term="%22Fahy+JV%22">Fahy JV</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Hastie+AT%22">Hastie AT</searchLink>; Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.<br /><searchLink fieldCode="AU" term="%22Jarjour+NN%22">Jarjour NN</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.<br /><searchLink fieldCode="AU" term="%22Khatri+PK%22">Khatri PK</searchLink>; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Meyers+DA%22">Meyers DA</searchLink>; Department of Medicine, Mayo Clinic, Scottsdale, AZ, 85259, USA.<br /><searchLink fieldCode="AU" term="%22Moore+WC%22">Moore WC</searchLink>; Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.<br /><searchLink fieldCode="AU" term="%22Ortega+VE%22">Ortega VE</searchLink>; Division of Respiratory Medicine, Department of Medicine, Mayo Clinic, Scottsdale, AZ, 85259, USA.<br /><searchLink fieldCode="AU" term="%22Phipatanakul+W%22">Phipatanakul W</searchLink>; Division of Allergy, Dermatology, Rheumatology, and Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Seibold+MA%22">Seibold MA</searchLink>; Center for Genes, Environment, and Health, Department of Pediatrics, National Jewish Health, Denver, CO, 80206, USA.<br /><searchLink fieldCode="AU" term="%22Sumino+K%22">Sumino K</searchLink>; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Wenzel+SE%22">Wenzel SE</searchLink>; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Woodruff+PG%22">Woodruff PG</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Mauger+DT%22">Mauger DT</searchLink>; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Israel+E%22">Israel E</searchLink>; 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