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Long-term real-world outcomes following preoperative radiotherapy and conservative surgery for trunk and extremity soft tissue sarcomas: a retrospective cohort study.

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Title: Long-term real-world outcomes following preoperative radiotherapy and conservative surgery for trunk and extremity soft tissue sarcomas: a retrospective cohort study.
Authors: Krcek R; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; University of Toronto, Toronto, Ontario, Canada., Wattakiyanon N; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada., Griffin AM; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Liu ZA; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Catton CN; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada., Roohani S; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Shultz DB; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada., Wong P; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada., Kirsch DG; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada., Othman HM; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.; Radiation Oncology Department, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Halifax, Nova Scotia, Canada.; Dalhousie University, Halifax, Nova Scotia, Canada., Ferguson PC; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Tsoi K; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Wunder JS; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Chung PWM; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.
Source: EClinicalMedicine [EClinicalMedicine] 2026 Jul 02; Vol. 97, pp. 104046. Date of Electronic Publication: 2026 Jul 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-term real-world outcomes following preoperative radiotherapy and conservative surgery for trunk and extremity soft tissue sarcomas: a retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Krcek+R%22">Krcek R</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wattakiyanon+N%22">Wattakiyanon N</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Griffin+AM%22">Griffin AM</searchLink>; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+ZA%22">Liu ZA</searchLink>; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Catton+CN%22">Catton CN</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Roohani+S%22">Roohani S</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Shultz+DB%22">Shultz DB</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+P%22">Wong P</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kirsch+DG%22">Kirsch DG</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Othman+HM%22">Othman HM</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.; Radiation Oncology Department, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Halifax, Nova Scotia, Canada.; Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Ferguson+PC%22">Ferguson PC</searchLink>; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Tsoi+K%22">Tsoi K</searchLink>; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Wunder+JS%22">Wunder JS</searchLink>; Department of Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Chung+PWM%22">Chung PWM</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.; University of Toronto, Toronto, Ontario, Canada.
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