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GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis.

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Title: GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis.
Authors: Shen S; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Chen K; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Li L; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Jiang M; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Jia Y; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Bai X; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Zeng Z; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Ma C; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Dang Y; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Hu K; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Chen Y; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Zhang W; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Miao Z; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China., Chen L; Department of Gastroenterology, Suining Central Hospital, Suining, Sichuan, China., Zhang H; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 26; Vol. 17, pp. 1799536. Date of Electronic Publication: 2026 Jun 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Jiang+M%22">Jiang M</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Bai+X%22">Bai X</searchLink>; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zeng+Z%22">Zeng Z</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Dang+Y%22">Dang Y</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Miao+Z%22">Miao Z</searchLink>; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Gastroenterology, Suining Central Hospital, Suining, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.; Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Inflammatory bowel disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jun 26; Vol. 17, pp. 1799536. <i>Date of Electronic Publication: </i>2026 Jun 26 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1799536
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        Text: English
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              Text: 2026 Jun 26
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