Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.

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Title: Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.
Authors: Lei L; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Zhou H; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Lai X; Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, China., Wang Z; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China., Li R; Department of Thyroid and Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China., Du C; Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., He X; Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China., Du L; Zhejiang Provincial Office for Cancer Prevention and Control, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China., Zheng Y; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Wang X; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. wxiaojia0803@163.com., Shao X; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. shaoxy@zjcc.org.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2026 Jul 11; Vol. 31 (8). Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-675X
DOI:10.1007/s10495-026-02388-x