Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.

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Title: Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.
Authors: Lei L; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Zhou H; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Lai X; Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, China., Wang Z; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China., Li R; Department of Thyroid and Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China., Du C; Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., He X; Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China., Du L; Zhejiang Provincial Office for Cancer Prevention and Control, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China., Zheng Y; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China., Wang X; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. wxiaojia0803@163.com., Shao X; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. shaoxy@zjcc.org.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2026 Jul 11; Vol. 31 (8). Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42435251
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.
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  Data: <searchLink fieldCode="AU" term="%22Lei+L%22">Lei L</searchLink>; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Lai+X%22">Lai X</searchLink>; Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Thyroid and Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Du+C%22">Du C</searchLink>; Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Du+L%22">Du L</searchLink>; Zhejiang Provincial Office for Cancer Prevention and Control, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. wxiaojia0803@163.com.<br /><searchLink fieldCode="AU" term="%22Shao+X%22">Shao X</searchLink>; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, No.1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang, China. shaoxy@zjcc.org.cn.
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  Data: <searchLink fieldCode="JN" term="%229712129%22">Apoptosis : an international journal on programmed cell death</searchLink> [Apoptosis] 2026 Jul 11; Vol. 31 (8). <i>Date of Electronic Publication: </i>2026 Jul 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9712129 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-675X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213608185%22">13608185 </searchLink><i>NLM ISO Abbreviation: </i>Apoptosis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10495-026-02388-x
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        Text: English
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      – TitleFull: Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication.
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            – D: 11
              M: 07
              Text: 2026 Jul 11
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