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Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.

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Title: Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.
Authors: Prieto-Utrera RD; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain., Bardají-Carrillo M; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., Gómez-Sánchez E; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain., Cobo-Zubia R; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain., Rebollo-Mato I; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain., Perez-Mazzali M; Mucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain., Matesanz-Isabel J; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain., Prada LS; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; National Influenza Centre, Valladolid, Spain., Tamayo-Velasco Á; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Hematology and Hemotherapy, University Clinical Hospital of Valladolid, Valladolid, Spain; Department of Medicine, Faculty of Medicine, University of Valladolid, Valladolid, Spain. Electronic address: alvaro.tamayo@uva.es., Martín-Fernández M; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain., Tovar-Doncel MS; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Toledo, Toledo, Spain., Adamove P; Department of Anesthesiology and Critical Care, Clinical Hospital of Bellvitge, Barcelona, Spain., Carrasco-Serrano E; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain., Cocho-Crespo S; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain., Fernández-Urbon A; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain., Fernández-Arranz M; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain., Eiros JM; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Microbiology, Río Hortega University Hospital, Valladolid, Spain; National Influenza Centre, Valladolid, Spain; Department of Microbiology, Faculty of Medicine, Universidad de Valladolid, Spain; Department of Microbiology, University Clinical Hospital of Valladolid, Valladolid, Spain., Sanz-Muñoz I; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; National Influenza Centre, Valladolid, Spain., Gonzalo-Benito H; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., López-Herrero R; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain., Aguilar G; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valencia, Valencia, Spain; Faculty of Medicine, University of Valencia, Valencia, Spain., Hornero R; Biomedical Engineering Group, University of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Carlos III Health Institute, Madrid, Spain., Ince C; Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Poves-Álvarez R; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain., Bernardo D; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Mucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain., Tamayo E; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain., García-Concejo A; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.
Source: EBioMedicine [EBioMedicine] 2026 Jul 11; Vol. 130, pp. 106372. Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.
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  Data: <searchLink fieldCode="AU" term="%22Prieto-Utrera+RD%22">Prieto-Utrera RD</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Bardají-Carrillo+M%22">Bardají-Carrillo M</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Sánchez+E%22">Gómez-Sánchez E</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Cobo-Zubia+R%22">Cobo-Zubia R</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Rebollo-Mato+I%22">Rebollo-Mato I</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Mazzali+M%22">Perez-Mazzali M</searchLink>; Mucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Matesanz-Isabel+J%22">Matesanz-Isabel J</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Prada+LS%22">Prada LS</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; National Influenza Centre, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Tamayo-Velasco+Á%22">Tamayo-Velasco Á</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Hematology and Hemotherapy, University Clinical Hospital of Valladolid, Valladolid, Spain; Department of Medicine, Faculty of Medicine, University of Valladolid, Valladolid, Spain. Electronic address: alvaro.tamayo@uva.es.<br /><searchLink fieldCode="AU" term="%22Martín-Fernández+M%22">Martín-Fernández M</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Tovar-Doncel+MS%22">Tovar-Doncel MS</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Toledo, Toledo, Spain.<br /><searchLink fieldCode="AU" term="%22Adamove+P%22">Adamove P</searchLink>; Department of Anesthesiology and Critical Care, Clinical Hospital of Bellvitge, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrasco-Serrano+E%22">Carrasco-Serrano E</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Cocho-Crespo+S%22">Cocho-Crespo S</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Urbon+A%22">Fernández-Urbon A</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Arranz+M%22">Fernández-Arranz M</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Eiros+JM%22">Eiros JM</searchLink>; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Microbiology, Río Hortega University Hospital, Valladolid, Spain; National Influenza Centre, Valladolid, Spain; Department of Microbiology, Faculty of Medicine, Universidad de Valladolid, Spain; Department of Microbiology, University Clinical Hospital of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-Muñoz+I%22">Sanz-Muñoz I</searchLink>; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; National Influenza Centre, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalo-Benito+H%22">Gonzalo-Benito H</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Herrero+R%22">López-Herrero R</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Aguilar+G%22">Aguilar G</searchLink>; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valencia, Valencia, Spain; Faculty of Medicine, University of Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Hornero+R%22">Hornero R</searchLink>; Biomedical Engineering Group, University of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ince+C%22">Ince C</searchLink>; Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Poves-Álvarez+R%22">Poves-Álvarez R</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Bernardo+D%22">Bernardo D</searchLink>; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Mucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Tamayo+E%22">Tamayo E</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Concejo+A%22">García-Concejo A</searchLink>; Group for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.
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