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Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.

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Title: Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.
Authors: Kinaciyan T; Department of Dermatology, ACARE and Hereditary Angioedema Center Vienna and Burgenland, Medical University of Vienna, Vienna, Austria., Aygören-Pürsün E; University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Martinez-Saguer I; HZRM Haemophilia Center Rhein Main, Frankfurt, Germany., Soteres DF; Asthma & Allergy Associates PC, Colorado Springs, Colo., Honda D; Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan., Manning ME; Department of Internal Medicine, UA College of Medicine, Phoenix, Ariz., Wedner HJ; Washington University School of Medicine, St Louis, Mo., Fukunaga A; Department of Dermatology/OMPU Allergy Center, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan., Kanarek HJ; Kanarek Adult & Pediatric Allergy, Asthma & Immunology, Overland Park, Kan., Ohmura K; Institute of Preventive Medical Sciences, Health Sciences University of Hokkaido, Sapporo, Japan., Melamed I; IMMUNOe Research Center, Centennial, Colo., El-Shanawany T; Department of Immunology, University Hospital of Wales, Cardiff, United Kingdom., Bouillet L; University of Grenoble Alpes, T-RAIG Unit, CNRS, UMR 5525, CHU Grenoble Alpes, TIMC, Grenoble, France.; French National Reference Center for Angioedema (CREAK), Internal Medicine Department, Grenoble University Hospital, Grenoble, France., Lumry WR; AARA Research Center, Dallas, Tex., Riedl MA; University of California-San Diego, La Jolla, Calif., Koleilat M; Deaconess Clinic, Evansville, Ind., Geng B; Allergy Asthma Medical Group & Research Center (AAMGRC), San Diego, Calif., Ohsawa I; Department of Nephrology, Saiyu Soka Hospital, Saitama, Japan., Bara N; Hereditary Angioedema Expertise Center, Sangeorgiu de Mures, Romania.; Mediquest Clinical Research Center, Sangeorgiu de Mures, Romania., Rehman S; Toledo Institute of Clinical Research, Toledo, Ohio., Bernstein JA; University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati, Ohio., Busse PJ; Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY., Cancian M; Departmental Allergy Division, Department of Systems Medicine, University of Padua, Padua, Italy., Cohn DM; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Craig TJ; Department of Medicine, Pediatrics, MFM and Biomedical Sciences, Penn State University, Hershey, Pa.; Vinmec-VinUni Institute of Immunology, Vin University, Hanoi, Vietnam.; Center of Allergy and Clinical Immunology, Vinmec Times City Hospital, Hanoi, Vietnam., Farkas H; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Kiani-Alikhan S; Division of Infection and Immunity, University College London, Royal Free London NHS Foundation Trust, London, United Kingdom., Li HH; Institute for Asthma and Allergy, Wheaton, Md., Raasch JP; Midwest Immunology Clinic, Plymouth, Minn., Tachdjian R; Division of Allergy and Clinical Immunology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif.; Allergy and Immunology, Providence Saint John's Health Center, Santa Monica, Calif., Audhya PK; KalVista Pharmaceuticals, Framingham, Mass., Bajcic P; KalVista Pharmaceuticals, Framingham, Mass., Chuang YH; KalVista Pharmaceuticals, Framingham, Mass., Iverson M; KalVista Pharmaceuticals, Framingham, Mass., Smith MD; KalVista Pharmaceuticals, Framingham, Mass., Yea CM; KalVista Pharmaceuticals, Framingham, Mass., Zanichelli A; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; Dipartimento di Scienze Biomediche per la Salute, University of Milan, Milan, Italy.
Source: The journal of allergy and clinical immunology. Global [J Allergy Clin Immunol Glob] 2026 Jun 12; Vol. 5 (5), pp. 100750. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918453488706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-8293 (Electronic) Linking ISSN: 27728293 NLM ISO Abbreviation: J Allergy Clin Immunol Glob Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.
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  Data: <searchLink fieldCode="AU" term="%22Kinaciyan+T%22">Kinaciyan T</searchLink>; Department of Dermatology, ACARE and Hereditary Angioedema Center Vienna and Burgenland, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Aygören-Pürsün+E%22">Aygören-Pürsün E</searchLink>; University Hospital Frankfurt, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Martinez-Saguer+I%22">Martinez-Saguer I</searchLink>; HZRM Haemophilia Center Rhein Main, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Soteres+DF%22">Soteres DF</searchLink>; Asthma & Allergy Associates PC, Colorado Springs, Colo.<br /><searchLink fieldCode="AU" term="%22Honda+D%22">Honda D</searchLink>; Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Manning+ME%22">Manning ME</searchLink>; Department of Internal Medicine, UA College of Medicine, Phoenix, Ariz.<br /><searchLink fieldCode="AU" term="%22Wedner+HJ%22">Wedner HJ</searchLink>; Washington University School of Medicine, St Louis, Mo.<br /><searchLink fieldCode="AU" term="%22Fukunaga+A%22">Fukunaga A</searchLink>; Department of Dermatology/OMPU Allergy Center, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kanarek+HJ%22">Kanarek HJ</searchLink>; Kanarek Adult & Pediatric Allergy, Asthma & Immunology, Overland Park, Kan.<br /><searchLink fieldCode="AU" term="%22Ohmura+K%22">Ohmura K</searchLink>; Institute of Preventive Medical Sciences, Health Sciences University of Hokkaido, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Melamed+I%22">Melamed I</searchLink>; IMMUNOe Research Center, Centennial, Colo.<br /><searchLink fieldCode="AU" term="%22El-Shanawany+T%22">El-Shanawany T</searchLink>; Department of Immunology, University Hospital of Wales, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bouillet+L%22">Bouillet L</searchLink>; University of Grenoble Alpes, T-RAIG Unit, CNRS, UMR 5525, CHU Grenoble Alpes, TIMC, Grenoble, France.; French National Reference Center for Angioedema (CREAK), Internal Medicine Department, Grenoble University Hospital, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Lumry+WR%22">Lumry WR</searchLink>; AARA Research Center, Dallas, Tex.<br /><searchLink fieldCode="AU" term="%22Riedl+MA%22">Riedl MA</searchLink>; University of California-San Diego, La Jolla, Calif.<br /><searchLink fieldCode="AU" term="%22Koleilat+M%22">Koleilat M</searchLink>; Deaconess Clinic, Evansville, Ind.<br /><searchLink fieldCode="AU" term="%22Geng+B%22">Geng B</searchLink>; Allergy Asthma Medical Group & Research Center (AAMGRC), San Diego, Calif.<br /><searchLink fieldCode="AU" term="%22Ohsawa+I%22">Ohsawa I</searchLink>; Department of Nephrology, Saiyu Soka Hospital, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Bara+N%22">Bara N</searchLink>; Hereditary Angioedema Expertise Center, Sangeorgiu de Mures, Romania.; Mediquest Clinical Research Center, Sangeorgiu de Mures, Romania.<br /><searchLink fieldCode="AU" term="%22Rehman+S%22">Rehman S</searchLink>; Toledo Institute of Clinical Research, Toledo, Ohio.<br /><searchLink fieldCode="AU" term="%22Bernstein+JA%22">Bernstein JA</searchLink>; University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Busse+PJ%22">Busse PJ</searchLink>; Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22Cancian+M%22">Cancian M</searchLink>; Departmental Allergy Division, Department of Systems Medicine, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Cohn+DM%22">Cohn DM</searchLink>; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Craig+TJ%22">Craig TJ</searchLink>; Department of Medicine, Pediatrics, MFM and Biomedical Sciences, Penn State University, Hershey, Pa.; Vinmec-VinUni Institute of Immunology, Vin University, Hanoi, Vietnam.; Center of Allergy and Clinical Immunology, Vinmec Times City Hospital, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Farkas+H%22">Farkas H</searchLink>; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Kiani-Alikhan+S%22">Kiani-Alikhan S</searchLink>; Division of Infection and Immunity, University College London, Royal Free London NHS Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Li+HH%22">Li HH</searchLink>; Institute for Asthma and Allergy, Wheaton, Md.<br /><searchLink fieldCode="AU" term="%22Raasch+JP%22">Raasch JP</searchLink>; Midwest Immunology Clinic, Plymouth, Minn.<br /><searchLink fieldCode="AU" term="%22Tachdjian+R%22">Tachdjian R</searchLink>; Division of Allergy and Clinical Immunology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif.; Allergy and Immunology, Providence Saint John's Health Center, Santa Monica, Calif.<br /><searchLink fieldCode="AU" term="%22Audhya+PK%22">Audhya PK</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Bajcic+P%22">Bajcic P</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Chuang+YH%22">Chuang YH</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Iverson+M%22">Iverson M</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Smith+MD%22">Smith MD</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Yea+CM%22">Yea CM</searchLink>; KalVista Pharmaceuticals, Framingham, Mass.<br /><searchLink fieldCode="AU" term="%22Zanichelli+A%22">Zanichelli A</searchLink>; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; Dipartimento di Scienze Biomediche per la Salute, University of Milan, Milan, Italy.
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