Effectiveness and safety of enfortumab vedotin and pembrolizumab in a real-world patient population with urothelial carcinoma: results from a multi-institutional cohort (GUARDIANS).
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| Title: | Effectiveness and safety of enfortumab vedotin and pembrolizumab in a real-world patient population with urothelial carcinoma: results from a multi-institutional cohort (GUARDIANS). |
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| Authors: | Zschäbitz S; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. Stefanie.zschaebitz@med.uni-heidelberg.de., Bhatti I; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany., Casuscelli J; Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany., Pachmayr LO; School of Medicine and Health, Department of Urology, Technical University of Munich, TUM University Hospital, Munich, Germany., Büttner T; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany., Elegeert T; Department of Urology and Pediatric Urology, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany., Holzwarth N; Department of Urology and Pediatric Urology, University Hospital Würzburg, Würzburg, Germany., Rodler S; Department of Urology, University Hospital Schleswig Holstein, Kiel, Germany., Hennig M; Hospital Am Urban, Berlin, Germany., Rinderknecht E; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany., Dib M; Department of Urology, University Hospital Düsseldorf, Düsseldorf, Germany., Schlack K; Department of Urology, University Hospital Muenster, Muenster, Germany., Darr C; Department of Urology, German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany., Volk AL; Department of Urology, University Hospital Magdeburg, Magdeburg, Germany., Schmucker P; Department of Urology, University Hospital Freiburg, Freiburg, Germany., Zengerling F; Department of Urology Und Paediatric Urology, Hospital University of Ulm, Ulm, Germany., Paffenholz P; Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Heil J; Department of Hematology, Oncology, Palliative Care, Heilbronn Hospital, Heilbronn, Germany., Erne E; Department of Urology, Hospital University of Tübingen, Tübingen, Germany., Mandal S; Department of Urology, University Hospital Marburg and Philipps University Marburg, Marburg, Germany.; Department of Urology, Heidelberg University Hospital, Heidelberg, Germany., Wessels F; Department of Urology and Urological Surgery, University Medical Centre Mannheim, Mannheim, Germany., Busse TM; Department Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Medical University Hannover, Hannover, Germany., Seidl D; Department of Urology, Diakonie-Klinikum Stuttgart, Stuttgart, Germany., Foller S; Urology Department, Jena University Hospital, Jena, Germany.; Department of Urology, SRH Hospital, Gera, Germany., Höllein A; Department of Oncology, Red Cross Hospital, Munich, Germany.; Veramed Hospital, Brannenburg, Germany., Nestler T; Department of Urology, Bundeswehrkrankenhaus Koblenz, Koblenz, Germany., Gratzke C; Department of Urology, University Hospital Freiburg, Freiburg, Germany., Rhode L; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany., Kohler J; Department of Urology, University Hospital Schleswig Holstein, Kiel, Germany., Niegisch G; Department of Urology, University Hospital Düsseldorf, Düsseldorf, Germany., Seitz AK; Department of Urology and Pediatric Urology, University Hospital Würzburg, Würzburg, Germany., Heinzelbecker J; Department of Urology and Pediatric Urology, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany.; Department of Urology, University Hospital Marburg and Philipps-University Marburg, Marburg, Germany., Klümper N; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany., Retz M; School of Medicine and Health, Department of Urology, Technical University of Munich, TUM University Hospital, Munich, Germany., Grünwald V; Institute for Urologic Oncology, West-German Cancer Center Essen, University Hospital Essen and German Cancer Consortium (DKTK), Essen, Germany., Aydogdu C; Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany., Schnabel MJ; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany. |
| Source: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Jul 12; Vol. 75 (7). Date of Electronic Publication: 2026 Jul 12. |
| Publication Type: | Journal Article; Multicenter Study |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42437411 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effectiveness and safety of enfortumab vedotin and pembrolizumab in a real-world patient population with urothelial carcinoma: results from a multi-institutional cohort (GUARDIANS). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Zschäbitz+S%22">Zschäbitz S</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. Stefanie.zschaebitz@med.uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Bhatti+I%22">Bhatti I</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Casuscelli+J%22">Casuscelli J</searchLink>; Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pachmayr+LO%22">Pachmayr LO</searchLink>; School of Medicine and Health, Department of Urology, Technical University of Munich, TUM University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Büttner+T%22">Büttner T</searchLink>; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Elegeert+T%22">Elegeert T</searchLink>; Department of Urology and Pediatric Urology, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany.<br /><searchLink fieldCode="AU" term="%22Holzwarth+N%22">Holzwarth N</searchLink>; Department of Urology and Pediatric Urology, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rodler+S%22">Rodler S</searchLink>; Department of Urology, University Hospital Schleswig Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Hennig+M%22">Hennig M</searchLink>; Hospital Am Urban, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rinderknecht+E%22">Rinderknecht E</searchLink>; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dib+M%22">Dib M</searchLink>; Department of Urology, University Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schlack+K%22">Schlack K</searchLink>; Department of Urology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Darr+C%22">Darr C</searchLink>; Department of Urology, German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Volk+AL%22">Volk AL</searchLink>; Department of Urology, University Hospital Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmucker+P%22">Schmucker P</searchLink>; Department of Urology, University Hospital Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zengerling+F%22">Zengerling F</searchLink>; Department of Urology Und Paediatric Urology, Hospital University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Paffenholz+P%22">Paffenholz P</searchLink>; Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Heil+J%22">Heil J</searchLink>; Department of Hematology, Oncology, Palliative Care, Heilbronn Hospital, Heilbronn, Germany.<br /><searchLink fieldCode="AU" term="%22Erne+E%22">Erne E</searchLink>; Department of Urology, Hospital University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mandal+S%22">Mandal S</searchLink>; Department of Urology, University Hospital Marburg and Philipps University Marburg, Marburg, Germany.; Department of Urology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wessels+F%22">Wessels F</searchLink>; Department of Urology and Urological Surgery, University Medical Centre Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Busse+TM%22">Busse TM</searchLink>; Department Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Medical University Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Seidl+D%22">Seidl D</searchLink>; Department of Urology, Diakonie-Klinikum Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Foller+S%22">Foller S</searchLink>; Urology Department, Jena University Hospital, Jena, Germany.; Department of Urology, SRH Hospital, Gera, Germany.<br /><searchLink fieldCode="AU" term="%22Höllein+A%22">Höllein A</searchLink>; Department of Oncology, Red Cross Hospital, Munich, Germany.; Veramed Hospital, Brannenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nestler+T%22">Nestler T</searchLink>; Department of Urology, Bundeswehrkrankenhaus Koblenz, Koblenz, Germany.<br /><searchLink fieldCode="AU" term="%22Gratzke+C%22">Gratzke C</searchLink>; Department of Urology, University Hospital Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rhode+L%22">Rhode L</searchLink>; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kohler+J%22">Kohler J</searchLink>; Department of Urology, University Hospital Schleswig Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Niegisch+G%22">Niegisch G</searchLink>; Department of Urology, University Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Seitz+AK%22">Seitz AK</searchLink>; Department of Urology and Pediatric Urology, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heinzelbecker+J%22">Heinzelbecker J</searchLink>; Department of Urology and Pediatric Urology, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany.; Department of Urology, University Hospital Marburg and Philipps-University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klümper+N%22">Klümper N</searchLink>; Department of Urology, University Hospital Bonn (UKB), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Retz+M%22">Retz M</searchLink>; School of Medicine and Health, Department of Urology, Technical University of Munich, TUM University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Grünwald+V%22">Grünwald V</searchLink>; Institute for Urologic Oncology, West-German Cancer Center Essen, University Hospital Essen and German Cancer Consortium (DKTK), Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Aydogdu+C%22">Aydogdu C</searchLink>; Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schnabel+MJ%22">Schnabel MJ</searchLink>; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2026 Jul 12; Vol. 75 (7). <i>Date of Electronic Publication: </i>2026 Jul 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42437411 |
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