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Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care.

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Title: Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care.
Authors: Needham DM; Division of Pulmonary and Critical Care Medicine and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Files DC; Section of Pulmonary, Critical Care, Allergy and Immunology, Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States., Hough CL; Division of Pulmonary, Allergy and Critical Care Medicine, Oregon Health and Science University, Portland, OR, United States., Mayer KP; Department of Physical Therapy, University of Kentucky, Lexington, KY, United States., Ardren S; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Fatima A; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Jiang X; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada., Day AG; Research Institute, Kingston Health Sciences Centre, Kingston, ON, Canada., Dinglas VD; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Hiser SL; Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, United States., Kiyatkin ME; Department of Anesthesiology, Montefiore Medical Center, Bronx, NY, United States., Khan A; Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health and Sciences University, Portland, OR, United States., Morris PE; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States., Carson SS; Division of Pulmonary and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States., Antkowiak M; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Bakhru RN; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, United States., Burns S; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Nath SD; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Gibbs KW; Section of Pulmonary, Critical Care, Allergy and Immunology, Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States., Gundel SJ; Division of Pulmonary, Critical Care and Sleep Medicine, Harborview Medical Center,Seattle, WA, United States., Kalema AG; Department of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY, United States., Sturgill JL; Department of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY, United States., Ventrone S; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Heyland DK; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada., Stapleton RD; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.
Corporate Authors: With The NEXIS Study Team
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care.
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  Data: <searchLink fieldCode="AU" term="%22Needham+DM%22">Needham DM</searchLink>; Division of Pulmonary and Critical Care Medicine and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Files+DC%22">Files DC</searchLink>; Section of Pulmonary, Critical Care, Allergy and Immunology, Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States.<br /><searchLink fieldCode="AU" term="%22Hough+CL%22">Hough CL</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, Oregon Health and Science University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Mayer+KP%22">Mayer KP</searchLink>; Department of Physical Therapy, University of Kentucky, Lexington, KY, United States.<br /><searchLink fieldCode="AU" term="%22Ardren+S%22">Ardren S</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.<br /><searchLink fieldCode="AU" term="%22Fatima+A%22">Fatima A</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Day+AG%22">Day AG</searchLink>; Research Institute, Kingston Health Sciences Centre, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dinglas+VD%22">Dinglas VD</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Hiser+SL%22">Hiser SL</searchLink>; Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Kiyatkin+ME%22">Kiyatkin ME</searchLink>; Department of Anesthesiology, Montefiore Medical Center, Bronx, NY, United States.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health and Sciences University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Morris+PE%22">Morris PE</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.<br /><searchLink fieldCode="AU" term="%22Carson+SS%22">Carson SS</searchLink>; Division of Pulmonary and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Antkowiak+M%22">Antkowiak M</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.<br /><searchLink fieldCode="AU" term="%22Bakhru+RN%22">Bakhru RN</searchLink>; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, United States.<br /><searchLink fieldCode="AU" term="%22Burns+S%22">Burns S</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.<br /><searchLink fieldCode="AU" term="%22Nath+SD%22">Nath SD</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Gibbs+KW%22">Gibbs KW</searchLink>; Section of Pulmonary, Critical Care, Allergy and Immunology, Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States.<br /><searchLink fieldCode="AU" term="%22Gundel+SJ%22">Gundel SJ</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Harborview Medical Center,Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Kalema+AG%22">Kalema AG</searchLink>; Department of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY, United States.<br /><searchLink fieldCode="AU" term="%22Sturgill+JL%22">Sturgill JL</searchLink>; Department of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY, United States.<br /><searchLink fieldCode="AU" term="%22Ventrone+S%22">Ventrone S</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.<br /><searchLink fieldCode="AU" term="%22Heyland+DK%22">Heyland DK</searchLink>; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stapleton+RD%22">Stapleton RD</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Thoracic+Society%22">American Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421642 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1535-4970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221073449X%22">1073449X </searchLink><i>NLM ISO Abbreviation: </i>Am J Respir Crit Care Med <i>Subsets: </i>MEDLINE
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