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Salivary Methotrexate as a Predictor of Oral Mucositis in Hematological Cancer Patients: A Phase II Randomized, Double-Blind Clinical Trial.

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Title: Salivary Methotrexate as a Predictor of Oral Mucositis in Hematological Cancer Patients: A Phase II Randomized, Double-Blind Clinical Trial.
Authors: Rodrigues-Oliveira L; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Bonfim CG; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Mores AL; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Palmier NR; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Abdalla HB; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil., Clemente-Napimoga JT; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil., Aquino IG; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil., de Oliveira MCQ; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Cuzzullin MC; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Filho AJV; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Rivera C; Laboratorio de Histopatología Oral y Maxilofacial, Unidad de Medicina Oral y Patología Oral, Departamento de Estomatología, Facultad de Odontología, Universidad de Talca, Talca, Región del Maule, Chile., Toporcov TN; Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, São Paulo, Brazil., Pereira J; Discipline of Hematology, University of São Paulo, São Paulo, Brazil., Gueiros LA; Department of Clinic and Preventive Dentistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil., López RVM; Comprehensive Center for Precision Oncology C2PO, Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Martins MD; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Lamers ML; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.; Basic Research Center in Dentistry, Dentistry School, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Morais-Faria K; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Vargas PA; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil., Santos-Silva AR; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil., Brandão TB; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil., Prado-Ribeiro AC; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.
Source: Oral diseases [Oral Dis] 2026 Jul 12. Date of Electronic Publication: 2026 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Salivary Methotrexate as a Predictor of Oral Mucositis in Hematological Cancer Patients: A Phase II Randomized, Double-Blind Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Rodrigues-Oliveira+L%22">Rodrigues-Oliveira L</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Bonfim+CG%22">Bonfim CG</searchLink>; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Mores+AL%22">Mores AL</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Palmier+NR%22">Palmier NR</searchLink>; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Abdalla+HB%22">Abdalla HB</searchLink>; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Clemente-Napimoga+JT%22">Clemente-Napimoga JT</searchLink>; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Aquino+IG%22">Aquino IG</searchLink>; Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+MCQ%22">de Oliveira MCQ</searchLink>; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cuzzullin+MC%22">Cuzzullin MC</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Filho+AJV%22">Filho AJV</searchLink>; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rivera+C%22">Rivera C</searchLink>; Laboratorio de Histopatología Oral y Maxilofacial, Unidad de Medicina Oral y Patología Oral, Departamento de Estomatología, Facultad de Odontología, Universidad de Talca, Talca, Región del Maule, Chile.<br /><searchLink fieldCode="AU" term="%22Toporcov+TN%22">Toporcov TN</searchLink>; Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+J%22">Pereira J</searchLink>; Discipline of Hematology, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gueiros+LA%22">Gueiros LA</searchLink>; Department of Clinic and Preventive Dentistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22López+RVM%22">López RVM</searchLink>; Comprehensive Center for Precision Oncology C2PO, Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+MD%22">Martins MD</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Lamers+ML%22">Lamers ML</searchLink>; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.; Basic Research Center in Dentistry, Dentistry School, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Morais-Faria+K%22">Morais-Faria K</searchLink>; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Vargas+PA%22">Vargas PA</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos-Silva+AR%22">Santos-Silva AR</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Brandão+TB%22">Brandão TB</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Prado-Ribeiro+AC%22">Prado-Ribeiro AC</searchLink>; Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.; Dental Oncology Service, Instituto Do Câncer Do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.; National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT-BIOFOTO BUCAL), Porto Alegre, Brazil.
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