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Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.

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Title: Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.
Authors: Kamel EM; Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62514 Egypt drnohascience@science.bsu.edu.eg., Khadrawy SM; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia., Ali MAM; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia., Ahmed NA; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University P.O. Box 62521 Beni-Suef Egypt., Alkhedhairi S; Department of Medical Biosciences, College of Veterinary Medicine, Qassim University P.O. Box 6622 Buraydah 51452 Saudi Arabia., Aba Alkhayl FF; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University Buraydah 51452 Saudi Arabia., Lamsabhi AM; Departamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid 28049 Madrid Spain.
Source: RSC advances [RSC Adv] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article; Review
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv
Database: MEDLINE Ultimate
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  Data: Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.
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  Data: <searchLink fieldCode="AU" term="%22Kamel+EM%22">Kamel EM</searchLink>; Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62514 Egypt drnohascience@science.bsu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Khadrawy+SM%22">Khadrawy SM</searchLink>; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ali+MAM%22">Ali MAM</searchLink>; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ahmed+NA%22">Ahmed NA</searchLink>; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University P.O. Box 62521 Beni-Suef Egypt.<br /><searchLink fieldCode="AU" term="%22Alkhedhairi+S%22">Alkhedhairi S</searchLink>; Department of Medical Biosciences, College of Veterinary Medicine, Qassim University P.O. Box 6622 Buraydah 51452 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aba+Alkhayl+FF%22">Aba Alkhayl FF</searchLink>; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University Buraydah 51452 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Lamsabhi+AM%22">Lamsabhi AM</searchLink>; Departamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid 28049 Madrid Spain.
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  Data: <searchLink fieldCode="JN" term="%22101581657%22">RSC advances</searchLink> [RSC Adv] 2026 Jul 06. <i>Date of Electronic Publication: </i>2026 Jul 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101581657 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2046-2069 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220462069%22">20462069 </searchLink><i>NLM ISO Abbreviation: </i>RSC Adv
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        Value: 10.1039/d6ra01334a
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      – TitleFull: Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.
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              Text: 2026 Jul 06
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              Y: 2026
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