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Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.

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Title: Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.
Authors: Sayed M; School of Materials and Chemistry, Southwest University of Science and Technology Mianyang 621010 China.; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Mohammed E; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Aboubaker DH; Medicinal and Aromatic Plants Department, Pharmaceutical and Drug Industries Institute, National Research Centre Dokki Giza 12622 Egypt., El-Rashedy AA; Natural and Microbial Products Department, National Research Center (NRC) Cairo 12622 Egypt., Hassanien R; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Tolba MS; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Ahmed M; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.
Source: RSC advances [RSC Adv] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv
Database: MEDLINE Ultimate
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  Data: Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.
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  Data: <searchLink fieldCode="AU" term="%22Sayed+M%22">Sayed M</searchLink>; School of Materials and Chemistry, Southwest University of Science and Technology Mianyang 621010 China.; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mohammed+E%22">Mohammed E</searchLink>; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.<br /><searchLink fieldCode="AU" term="%22Aboubaker+DH%22">Aboubaker DH</searchLink>; Medicinal and Aromatic Plants Department, Pharmaceutical and Drug Industries Institute, National Research Centre Dokki Giza 12622 Egypt.<br /><searchLink fieldCode="AU" term="%22El-Rashedy+AA%22">El-Rashedy AA</searchLink>; Natural and Microbial Products Department, National Research Center (NRC) Cairo 12622 Egypt.<br /><searchLink fieldCode="AU" term="%22Hassanien+R%22">Hassanien R</searchLink>; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.<br /><searchLink fieldCode="AU" term="%22Tolba+MS%22">Tolba MS</searchLink>; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.<br /><searchLink fieldCode="AU" term="%22Ahmed+M%22">Ahmed M</searchLink>; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%22101581657%22">RSC advances</searchLink> [RSC Adv] 2026 Jul 06. <i>Date of Electronic Publication: </i>2026 Jul 06.
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      – Type: doi
        Value: 10.1039/d6ra03908a
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      – Code: eng
        Text: English
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      – TitleFull: Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.
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            NameFull: Sayed M
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            NameFull: Mohammed E
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            NameFull: Aboubaker DH
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            – D: 06
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              Text: 2026 Jul 06
              Type: published
              Y: 2026
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              Value: 2046-2069
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