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Generating evidence using electronic alerts during routine care: a fully automated randomized controlled trial of oral fluid restriction in acute heart failure (THIRST alert trial).

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Title: Generating evidence using electronic alerts during routine care: a fully automated randomized controlled trial of oral fluid restriction in acute heart failure (THIRST alert trial).
Authors: Chen Y; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK., Higgins D; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK., Jani Y; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.; Research Department of Practice and Policy, School of Pharmacy, University College London, London WC1E 6BT, UK., Saleem N; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK., Chafer K; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK., McFarlane E; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK., Roberts T; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK., Harris S; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK., Williams B; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK., Sydes MR; Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, Gower Street, London WC1E 6BT, UK., Asselbergs FW; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Shah AD; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK., Lumbers RT; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.
Source: European heart journal. Digital health [Eur Heart J Digit Health] 2026 Jun 23; Vol. 7 (6), pp. ztag098. Date of Electronic Publication: 2026 Jun 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101778323 Publication Model: eCollection Cited Medium: Internet ISSN: 2634-3916 (Electronic) Linking ISSN: 26343916 NLM ISO Abbreviation: Eur Heart J Digit Health Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Higgins+D%22">Higgins D</searchLink>; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Jani+Y%22">Jani Y</searchLink>; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.; Research Department of Practice and Policy, School of Pharmacy, University College London, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Saleem+N%22">Saleem N</searchLink>; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Chafer+K%22">Chafer K</searchLink>; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22McFarlane+E%22">McFarlane E</searchLink>; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+T%22">Roberts T</searchLink>; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Harris+S%22">Harris S</searchLink>; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Williams+B%22">Williams B</searchLink>; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Sydes+MR%22">Sydes MR</searchLink>; Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, Gower Street, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Asselbergs+FW%22">Asselbergs FW</searchLink>; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Shah+AD%22">Shah AD</searchLink>; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Lumbers+RT%22">Lumbers RT</searchLink>; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, Gower Street, London WC1E 6BT, UK.; National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, 250 Euston Road, London NW1 2PG, UK.
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