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A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2.

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Title: A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2.
Authors: Patteson JB; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Manolaridis I; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Hong MR; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Johnston JM; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Mesbahi-Vasey S; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Gregory MC; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Iwamoto DV; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Reid JC; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Sanders JM; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Lovatt D; Neuroscience, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., McDonald TP; Neuroscience, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Shurtleff VW; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Gabelli SB; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Bukhtiyarova M; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jul 13, pp. 113322. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Jul 13, pp. 113322. <i>Date of Electronic Publication: </i>2026 Jul 13.
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