A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2.
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| Title: | A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2. |
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| Authors: | Patteson JB; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Manolaridis I; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Hong MR; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Johnston JM; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Mesbahi-Vasey S; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Gregory MC; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Iwamoto DV; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Reid JC; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Sanders JM; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Lovatt D; Neuroscience, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., McDonald TP; Neuroscience, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Shurtleff VW; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Gabelli SB; Discovery Chemistry, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA., Bukhtiyarova M; Quantitative Biosciences, Merck & Co., Inc., MRL, West Point, Pennsylvania 19486, USA. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2026 Jul 13, pp. 113322. Date of Electronic Publication: 2026 Jul 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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