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Detection of seizurogenic compounds in human and rat neurons in vitro: a multi-laboratory, multi-model assessment.

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Title: Detection of seizurogenic compounds in human and rat neurons in vitro: a multi-laboratory, multi-model assessment.
Authors: Roberts R; ApconiX, Macclesfield SK10 4TG, UK; Department of Biosciences, University of Birmingham, Edgbaston B15 1TT, UK., Blinova K; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US. Food and Drug Administration, Silver Spring, MD USA., Carlson C; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Cato M; GSK, Collegeville, PA, USA., Czysz K; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Feaster TK; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US. Food and Drug Administration, Silver Spring, MD USA., Han X; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan., Ishibashi Y; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan., Kanda Y; Division of Pharmacology, National Institute of Health Sciences (NIHS) Japan., Kreir M; Johnson and Johnson Innovative Medicine, 2340 Beerse, Belgium., Levesque P; Bristol-Myers Squib, NJ, USA., Miyamoto N; Eisai, Tsukuba, Japan., Pierson JB; Health and Environmental Sciences Institute, Washington, DC, USA. Electronic address: jpierson@hesiglobal.org., Shafer TJ; Shafer Neurotox Consulting, LLC, Durham, NC USA., Schachtele S; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Strock C; Cyprotex, Watertown, USA., Yoshinaga T; Eisai, Tsukuba, Japan., Suzuki I; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan.
Source: Neurotoxicology [Neurotoxicology] 2026 Jul 13, pp. 103519. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE
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  Data: Detection of seizurogenic compounds in human and rat neurons in vitro: a multi-laboratory, multi-model assessment.
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  Data: <searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; ApconiX, Macclesfield SK10 4TG, UK; Department of Biosciences, University of Birmingham, Edgbaston B15 1TT, UK.<br /><searchLink fieldCode="AU" term="%22Blinova+K%22">Blinova K</searchLink>; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US. Food and Drug Administration, Silver Spring, MD USA.<br /><searchLink fieldCode="AU" term="%22Carlson+C%22">Carlson C</searchLink>; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Cato+M%22">Cato M</searchLink>; GSK, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Czysz+K%22">Czysz K</searchLink>; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Feaster+TK%22">Feaster TK</searchLink>; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US. Food and Drug Administration, Silver Spring, MD USA.<br /><searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan.<br /><searchLink fieldCode="AU" term="%22Ishibashi+Y%22">Ishibashi Y</searchLink>; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan.<br /><searchLink fieldCode="AU" term="%22Kanda+Y%22">Kanda Y</searchLink>; Division of Pharmacology, National Institute of Health Sciences (NIHS) Japan.<br /><searchLink fieldCode="AU" term="%22Kreir+M%22">Kreir M</searchLink>; Johnson and Johnson Innovative Medicine, 2340 Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Levesque+P%22">Levesque P</searchLink>; Bristol-Myers Squib, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Miyamoto+N%22">Miyamoto N</searchLink>; Eisai, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Pierson+JB%22">Pierson JB</searchLink>; Health and Environmental Sciences Institute, Washington, DC, USA. Electronic address: jpierson@hesiglobal.org.<br /><searchLink fieldCode="AU" term="%22Shafer+TJ%22">Shafer TJ</searchLink>; Shafer Neurotox Consulting, LLC, Durham, NC USA.<br /><searchLink fieldCode="AU" term="%22Schachtele+S%22">Schachtele S</searchLink>; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Strock+C%22">Strock C</searchLink>; Cyprotex, Watertown, USA.<br /><searchLink fieldCode="AU" term="%22Yoshinaga+T%22">Yoshinaga T</searchLink>; Eisai, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+I%22">Suzuki I</searchLink>; Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, 35-1 Yagiyama Kasumicho, Taihaku-ku, Sendai 982-8577, Japan.
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  Data: <searchLink fieldCode="JN" term="%227905589%22">Neurotoxicology</searchLink> [Neurotoxicology] 2026 Jul 13, pp. 103519. <i>Date of Electronic Publication: </i>2026 Jul 13.
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