Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis.

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Title: Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis.
Authors: Chuang MH; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Ho CW; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Wang HY; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Pan HC; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Wu VC; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Tu YK; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Chen JY; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan. a50601@mail.chimei.org.tw.
Source: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2026 Jul 12; Vol. 198 (26), pp. E992-E1001. Date of Electronic Publication: 2026 Jul 12.
Publication Type: Journal Article; Network Meta-Analysis; Systematic Review
Journal Info: Publisher: Canadian Medical Association Country of Publication: Canada NLM ID: 9711805 Publication Model: Electronic Cited Medium: Internet ISSN: 1488-2329 (Electronic) Linking ISSN: 08203946 NLM ISO Abbreviation: CMAJ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1488-2329
DOI:10.1503/cmaj.250369