Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis.
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| Title: | Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis. |
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| Authors: | Chuang MH; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Ho CW; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Wang HY; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Pan HC; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Wu VC; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Tu YK; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Chen JY; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan. a50601@mail.chimei.org.tw. |
| Source: | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2026 Jul 12; Vol. 198 (26), pp. E992-E1001. Date of Electronic Publication: 2026 Jul 12. |
| Publication Type: | Journal Article; Network Meta-Analysis; Systematic Review |
| Journal Info: | Publisher: Canadian Medical Association Country of Publication: Canada NLM ID: 9711805 Publication Model: Electronic Cited Medium: Internet ISSN: 1488-2329 (Electronic) Linking ISSN: 08203946 NLM ISO Abbreviation: CMAJ Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42442791 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chuang+MH%22">Chuang MH</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+CW%22">Ho CW</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Pan+HC%22">Pan HC</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+VC%22">Wu VC</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tu+YK%22">Tu YK</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Division of Nephrology, Department of Internal Medicine (Chuang, Wang, Chen) and Department of Physical Medicine and Rehabilitation (Ho), Chi-Mei Medical Center, Tainan, Taiwan; Department of Sport Management (Wang), College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Division of Nephrology, Department of Internal Medicine (Pan), Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Nephrology, Department of Internal Medicine (Wu), National Taiwan University Hospital, Taipei, Taiwan; Institute of Health Data Analytics and Statistics (Tu), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health and Nutrition (Chen), Chia Nan University of Pharmacy and Science, Tainan, Taiwan. a50601@mail.chimei.org.tw. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229711805%22">CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne</searchLink> [CMAJ] 2026 Jul 12; Vol. 198 (26), pp. E992-E1001. <i>Date of Electronic Publication: </i>2026 Jul 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Network Meta-Analysis; Systematic Review – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Canadian+Medical+Association%22">Canadian Medical Association </searchLink><i>Country of Publication: </i>Canada <i>NLM ID: </i>9711805 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1488-2329 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208203946%22">08203946 </searchLink><i>NLM ISO Abbreviation: </i>CMAJ <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42442791 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1503/cmaj.250369 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: E992 Titles: – TitleFull: Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chuang MH – PersonEntity: Name: NameFull: Ho CW – PersonEntity: Name: NameFull: Wang HY – PersonEntity: Name: NameFull: Pan HC – PersonEntity: Name: NameFull: Wu VC – PersonEntity: Name: NameFull: Tu YK – PersonEntity: Name: NameFull: Chen JY IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 07 Text: 2026 Jul 12 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1488-2329 Numbering: – Type: volume Value: 198 – Type: issue Value: 26 Titles: – TitleFull: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Type: main |
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