Widespread white matter microstructural abnormalities in treatment‑naïve patients with first‑episode schizophrenia revealed by fixel-based analysis.

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Title: Widespread white matter microstructural abnormalities in treatment‑naïve patients with first‑episode schizophrenia revealed by fixel-based analysis.
Authors: Yang M; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Li H; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Li M; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China., Wang Q; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China., Deng L; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Zhao L; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China., Yu H; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Li X; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Deng W; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China., Guo W; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China., Wei W; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn., Li T; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jul 13; Vol. 16 (1). Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: Widespread white matter microstructural abnormalities in treatment‑naïve patients with first‑episode schizophrenia revealed by fixel-based analysis.
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  Data: <searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Deng+L%22">Deng L</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Deng+W%22">Deng W</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Guo+W%22">Guo W</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China. weiweih7@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Nanhu Brain-computer Interface Institute, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Zhejiang Key Laboratory of Clinical and Basic Research for Psychiatric Diseases, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, Zhejiang, China. litaozjusc@zju.edu.cn.
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        Value: 10.1038/s41398-026-04277-y
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