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PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation.

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Title: PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation.
Authors: Mori Y; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Suto K; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Takei N; Institute for Animal Experimentation, Hokkaido University Faculty of Medicine, Sapporo, Japan., Yokoyama K; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Chiba M; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Ishio T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Goto H; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Endo T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.; Department of Infection Control and Prevention, Hokkaido University Hospital, Sapporo, Japan., Hasegawa H; Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Maeda M; Institute for Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan., Otsuguro S; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan., Maenaka K; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan.; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo, 060 0812, Japan.; Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, 001-0020, Japan.; Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan., Teshima T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Yang Y; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Nakagawa M; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.; Department of Hematology, Hokkaido University Hospital, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.
Source: Leukemia [Leukemia] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation.
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  Data: <searchLink fieldCode="AU" term="%22Mori+Y%22">Mori Y</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Suto+K%22">Suto K</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takei+N%22">Takei N</searchLink>; Institute for Animal Experimentation, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoyama+K%22">Yokoyama K</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Chiba+M%22">Chiba M</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishio+T%22">Ishio T</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+H%22">Goto H</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Endo+T%22">Endo T</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.; Department of Infection Control and Prevention, Hokkaido University Hospital, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Hasegawa+H%22">Hasegawa H</searchLink>; Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, 852-8501, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+M%22">Maeda M</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Otsuguro+S%22">Otsuguro S</searchLink>; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan.<br /><searchLink fieldCode="AU" term="%22Maenaka+K%22">Maenaka K</searchLink>; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan.; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo, 060 0812, Japan.; Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, 001-0020, Japan.; Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Teshima+T%22">Teshima T</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nakagawa+M%22">Nakagawa M</searchLink>; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.; Department of Hematology, Hokkaido University Hospital, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.
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              Text: 2026 Jul 13
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