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An anti-PMEL antibody-drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.

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Title: An anti-PMEL antibody-drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.
Authors: Carlino MS; Westmead and Blacktown Hospitals, University of Sydney, Sydney, New South Wales, Australia. matteo.carlino@sydney.edu.au.; Melanoma Institute Australia, Sydney, New South Wales, Australia. matteo.carlino@sydney.edu.au., Kapiteijn E; Leiden University Medical Center, Leiden, The Netherlands., Piperno-Neumann S; Institut Curie, Paris, PSL Research University, Paris, France., Sullivan RJ; Massachusetts General Hospital, Boston, MA, USA., Carvajal R; Northwell Health Cancer Institute, Lake Success, NY, USA., Dummer R; University Hospital Zurich, Zurich, Switzerland., Gromke T; University Hospital Essen, Essen, Germany., Hassel JC; Heidelberg University, Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Heidelberg, Germany., Kee D; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia., Ramelyte E; University Hospital Zurich, Zurich, Switzerland., Shoushtari AN; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., Wei AZ; Columbia University Herbert Irving Comprehensive Cancer Center, New York-Presbyterian Hospital, New York, NY, USA., Enk A; Heidelberg University, Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Heidelberg, Germany., Handel EE; Westmead and Blacktown Hospitals, University of Sydney, Sydney, New South Wales, Australia., Montazeri K; Massachusetts General Hospital, Boston, MA, USA., Ramon-Patino J; START Madrid-CIOCC, Centro Integral Oncologico Clara Campal, Madrid, Spain., Richly H; University Hospital Essen, Essen, Germany., Rodrigues M; Institut Curie, Paris, PSL Research University, Paris, France., Sandhu S; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia., Smithy J; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., Speetjens FM; Leiden University Medical Center, Leiden, The Netherlands., Milanez-Almeida P; Biomedical Research, Novartis, Cambridge, MA, USA., Chaudhury A; Development, Novartis, Cambridge, MA, USA., Hoffmaster K; Biomedical Research, Novartis, Cambridge, MA, USA., Ising M; Biomedical Research, Novartis, East Hanover, NJ, USA., Otero JA; Biomedical Research, Novartis, East Hanover, NJ, USA., RamKumar T; Biomedical Research, Novartis, East Hanover, NJ, USA., Reynolds A; Biomedical Research, Novartis, Cambridge, MA, USA., Sharaby S; Biomedical Research, Novartis, East Hanover, NJ, USA., Werner L; Development, Novartis, Cambridge, MA, USA., Yerramilli-Rao P; Biomedical Research, Novartis, Cambridge, MA, USA., Calvo E; START Madrid-CIOCC, Centro Integral Oncologico Clara Campal, Madrid, Spain.
Source: Nature medicine [Nat Med] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hassel+JC%22">Hassel JC</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kee+D%22">Kee D</searchLink>; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ramelyte+E%22">Ramelyte E</searchLink>; University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shoushtari+AN%22">Shoushtari AN</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wei+AZ%22">Wei AZ</searchLink>; Columbia University Herbert Irving Comprehensive Cancer Center, New York-Presbyterian Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Enk+A%22">Enk A</searchLink>; 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Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Smithy+J%22">Smithy J</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Speetjens+FM%22">Speetjens FM</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Milanez-Almeida+P%22">Milanez-Almeida P</searchLink>; Biomedical Research, Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhury+A%22">Chaudhury A</searchLink>; Development, Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hoffmaster+K%22">Hoffmaster K</searchLink>; Biomedical Research, Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ising+M%22">Ising M</searchLink>; Biomedical Research, Novartis, East Hanover, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Otero+JA%22">Otero JA</searchLink>; 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