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A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.

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Title: A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.
Authors: Wang D; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wangduotc@gmail.com.; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA. wangduotc@gmail.com., Ming H; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA., Yang D; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Cui X; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Freeman Z; Transgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI, USA., Tsai LK; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Wei Z; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Liu L; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA., Scatolin GN; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA., Bennett B; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., Wang X; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., Yau K; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Tao L; Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, USA., Tong X; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wang S; Transgenic Mouse Facility, University of California, Irvine, CA, USA., Shi KX; Transgenic Mouse Facility, University of California, Irvine, CA, USA., Evseenko D; Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Van Handel B; Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Guo L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Dai X; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Xiong Y; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Zhang B; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wang Y; School of Animal Sciences, AgCenter, Louisiana State University, Baton Rouge, LA, USA., Iyyappan R; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA., Ojeda-Rojas OA; Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL, USA., Hu G; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., McGinnis L; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Paulson R; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mckim D; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kong X; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Xia X; ATGC Inc., Philadelphia, PA, USA., Zhang J; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Chen YE; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA., Jiang Z; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA. z.jiang1@ufl.edu., Xu J; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA. jiex@umich.edu., Ying QL; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. qying@med.usc.edu.
Source: Cell research [Cell Res] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.
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  Data: <searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wangduotc@gmail.com.; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA. wangduotc@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ming+H%22">Ming H</searchLink>; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Cui+X%22">Cui X</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+Z%22">Freeman Z</searchLink>; Transgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+LK%22">Tsai LK</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Scatolin+GN%22">Scatolin GN</searchLink>; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+B%22">Bennett B</searchLink>; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yau+K%22">Yau K</searchLink>; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tao+L%22">Tao L</searchLink>; Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Tong+X%22">Tong X</searchLink>; 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Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; School of Animal Sciences, AgCenter, Louisiana State University, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Iyyappan+R%22">Iyyappan R</searchLink>; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ojeda-Rojas+OA%22">Ojeda-Rojas OA</searchLink>; Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hu+G%22">Hu G</searchLink>; Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McGinnis+L%22">McGinnis L</searchLink>; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Paulson+R%22">Paulson R</searchLink>; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mckim+D%22">Mckim D</searchLink>; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xia+X%22">Xia X</searchLink>; ATGC Inc., Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YE%22">Chen YE</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA. z.jiang1@ufl.edu.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA. jiex@umich.edu.<br /><searchLink fieldCode="AU" term="%22Ying+QL%22">Ying QL</searchLink>; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. qying@med.usc.edu.
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