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Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.

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Title: Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.
Authors: Carver CM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Gomez PT; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Rodriguez SL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Redden JT; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Latham AS; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Ha Y; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Kachergus JM; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Liu Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Shi J; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Tran T; Buck Institute for Research on Aging, Novato, CA, USA., Wang L; Division of Computational Biology, Mayo Clinic College of Medicine, Rochester, MN, USA., Melov S; Buck Institute for Research on Aging, Novato, CA, USA., Thompson EA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Schafer MJ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. schafer.marissa@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. schafer.marissa@mayo.edu.; Department of Neurology, Mayo Clinic, Rochester, MN, USA. schafer.marissa@mayo.edu.; Department of Neuroscience, Mayo Clinic, Rochester, MN, USA. schafer.marissa@mayo.edu.
Source: Nature aging [Nat Aging] 2026 Jul; Vol. 6 (7), pp. 1417-1436. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Jul; Vol. 6 (7), pp. 1417-1436. <i>Date of Electronic Publication: </i>2026 Jul 13.
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              Text: 2026 Jul
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