View in EDS

Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.

Saved in:
Bibliographic Details
Title: Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.
Authors: Robles O; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Brockstedt DG; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Aponte-Guzman J; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Bradford D; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Chian D; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Colas C; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Grandcolas M; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Hu DX; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Jackson J; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Jacobson S; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Karbarz E; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Kassner PD; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Katibah GE; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Ketcham JM; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Marshall L; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., McKinnell J; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Meleza C; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Milestone H; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Okano A; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Qiu J; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Reilly MK; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Riegler E; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Shunatona HP; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Talay O; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Younai A; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Ziari N; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Zibinsky M; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States., Wustrow DJ; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42444067
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Robles+O%22">Robles O</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Brockstedt+DG%22">Brockstedt DG</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Aponte-Guzman+J%22">Aponte-Guzman J</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Bradford+D%22">Bradford D</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Chian+D%22">Chian D</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Colas+C%22">Colas C</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Grandcolas+M%22">Grandcolas M</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Hu+DX%22">Hu DX</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+J%22">Jackson J</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jacobson+S%22">Jacobson S</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Karbarz+E%22">Karbarz E</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Kassner+PD%22">Kassner PD</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Katibah+GE%22">Katibah GE</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Marshall+L%22">Marshall L</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22McKinnell+J%22">McKinnell J</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Meleza+C%22">Meleza C</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Milestone+H%22">Milestone H</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Okano+A%22">Okano A</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Qiu+J%22">Qiu J</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Reilly+MK%22">Reilly MK</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Riegler+E%22">Riegler E</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Shunatona+HP%22">Shunatona HP</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Talay+O%22">Talay O</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Younai+A%22">Younai A</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Ziari+N%22">Ziari N</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Zibinsky+M%22">Zibinsky M</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Wustrow+DJ%22">Wustrow DJ</searchLink>; RAPT Therapeutics, 561 Eccles Ave, South San Francisco, California 94080, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 13. <i>Date of Electronic Publication: </i>2026 Jul 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42444067
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.6c00683
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Robles O
      – PersonEntity:
          Name:
            NameFull: Brockstedt DG
      – PersonEntity:
          Name:
            NameFull: Aponte-Guzman J
      – PersonEntity:
          Name:
            NameFull: Bradford D
      – PersonEntity:
          Name:
            NameFull: Chian D
      – PersonEntity:
          Name:
            NameFull: Colas C
      – PersonEntity:
          Name:
            NameFull: Grandcolas M
      – PersonEntity:
          Name:
            NameFull: Hu DX
      – PersonEntity:
          Name:
            NameFull: Jackson J
      – PersonEntity:
          Name:
            NameFull: Jacobson S
      – PersonEntity:
          Name:
            NameFull: Karbarz E
      – PersonEntity:
          Name:
            NameFull: Kassner PD
      – PersonEntity:
          Name:
            NameFull: Katibah GE
      – PersonEntity:
          Name:
            NameFull: Ketcham JM
      – PersonEntity:
          Name:
            NameFull: Marshall L
      – PersonEntity:
          Name:
            NameFull: McKinnell J
      – PersonEntity:
          Name:
            NameFull: Meleza C
      – PersonEntity:
          Name:
            NameFull: Milestone H
      – PersonEntity:
          Name:
            NameFull: Okano A
      – PersonEntity:
          Name:
            NameFull: Qiu J
      – PersonEntity:
          Name:
            NameFull: Reilly MK
      – PersonEntity:
          Name:
            NameFull: Riegler E
      – PersonEntity:
          Name:
            NameFull: Shunatona HP
      – PersonEntity:
          Name:
            NameFull: Talay O
      – PersonEntity:
          Name:
            NameFull: Younai A
      – PersonEntity:
          Name:
            NameFull: Ziari N
      – PersonEntity:
          Name:
            NameFull: Zibinsky M
      – PersonEntity:
          Name:
            NameFull: Wustrow DJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 13
              M: 07
              Text: 2026 Jul 13
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1