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Case Report: A novel homozygous splice-site variant in the C3 gene causing complete complement C3 deficiency in two unrelated Moroccan patients.

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Title: Case Report: A novel homozygous splice-site variant in the C3 gene causing complete complement C3 deficiency in two unrelated Moroccan patients.
Authors: Oujane C; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco., Hbibi M; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Departement of Pediatric Hematology-Oncology, SHOP, CHU Hassan II, Fez, Morocco., Benhsaien I; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco., Naitobrah A; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco., Akhrichi N; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco., Aadam Z; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco., Kalil H; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco., El Bakkouri J; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Immuno-Serology Hospital Laboratory, Ibn Rochd University Hospital, Casablanca, Morocco., Bousfiha AA; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco., Ailal F; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 29; Vol. 17, pp. 1860941. Date of Electronic Publication: 2026 Jun 29 (Print Publication: 2026).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Case Report: A novel homozygous splice-site variant in the C3 gene causing complete complement C3 deficiency in two unrelated Moroccan patients.
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  Data: <searchLink fieldCode="AU" term="%22Oujane+C%22">Oujane C</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Hbibi+M%22">Hbibi M</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Departement of Pediatric Hematology-Oncology, SHOP, CHU Hassan II, Fez, Morocco.<br /><searchLink fieldCode="AU" term="%22Benhsaien+I%22">Benhsaien I</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Naitobrah+A%22">Naitobrah A</searchLink>; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Akhrichi+N%22">Akhrichi N</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Aadam+Z%22">Aadam Z</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Kalil+H%22">Kalil H</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22El+Bakkouri+J%22">El Bakkouri J</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Immuno-Serology Hospital Laboratory, Ibn Rochd University Hospital, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Bousfiha+AA%22">Bousfiha AA</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Ailal+F%22">Ailal F</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.; Department of Clinical Immunology and Pediatrics Infectious diseases, Abderrahim El Harouchi Mother Child Hospital, Ibn Rochd University Hospital Center, Casablanca, Morocco.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jun 29; Vol. 17, pp. 1860941. <i>Date of Electronic Publication: </i>2026 Jun 29 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 29
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