Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN.
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| Title: | Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN. |
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| Authors: | Kajol; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India., Choudhury A; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India., Banerjee A; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India., Shukla P; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India., Panda SJ; School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar 752050, India., Pathak RK; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16601-16628. Date of Electronic Publication: 2026 Jul 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42446174 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kajol%22">Kajol</searchLink>; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.<br /><searchLink fieldCode="AU" term="%22Choudhury+A%22">Choudhury A</searchLink>; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.<br /><searchLink fieldCode="AU" term="%22Banerjee+A%22">Banerjee A</searchLink>; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.<br /><searchLink fieldCode="AU" term="%22Shukla+P%22">Shukla P</searchLink>; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.<br /><searchLink fieldCode="AU" term="%22Panda+SJ%22">Panda SJ</searchLink>; School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar 752050, India.<br /><searchLink fieldCode="AU" term="%22Pathak+RK%22">Pathak RK</searchLink>; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16601-16628. <i>Date of Electronic Publication: </i>2026 Jul 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42446174 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.6c00253 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 16601 Titles: – TitleFull: Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kajol – PersonEntity: Name: NameFull: Choudhury A – PersonEntity: Name: NameFull: Banerjee A – PersonEntity: Name: NameFull: Shukla P – PersonEntity: Name: NameFull: Panda SJ – PersonEntity: Name: NameFull: Pathak RK IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 07 Text: 2026 Jul 23 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 69 – Type: issue Value: 14 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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