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Structural modification of (‒)-xanthorrhizol isolated from Curcuma aromatica rhizomes to analogs with potent nitric oxide inhibitory activities.

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Title: Structural modification of (‒)-xanthorrhizol isolated from Curcuma aromatica rhizomes to analogs with potent nitric oxide inhibitory activities.
Authors: Pabuprapap W; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand., Chaichompoo W; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand. waraluck.c@rumail.ru.ac.th., Pratumwan P; Health Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand., Sangsawat M; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand., Supaweera N; Health Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand., Chunglok W; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.; Food Technology and Innovation Center of Excellence, Research and Innovation Institute of Excellence, Walailak University, Nakhon Si Thammarat, 80160, Thailand., Rahmadani A; Department of Chemistry Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, 75123, East Kalimantan, Indonesia., Ajavakom V; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand., Rojsitthisak P; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand., Suksamrarn A; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.
Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2026 Mar; Vol. 35 (3), pp. 581-593. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8120 (Electronic) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: MEDLINE
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  Data: Structural modification of (‒)-xanthorrhizol isolated from Curcuma aromatica rhizomes to analogs with potent nitric oxide inhibitory activities.
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  Data: <searchLink fieldCode="AU" term="%22Pabuprapap+W%22">Pabuprapap W</searchLink>; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.<br /><searchLink fieldCode="AU" term="%22Chaichompoo+W%22">Chaichompoo W</searchLink>; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand. waraluck.c@rumail.ru.ac.th.<br /><searchLink fieldCode="AU" term="%22Pratumwan+P%22">Pratumwan P</searchLink>; Health Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.<br /><searchLink fieldCode="AU" term="%22Sangsawat+M%22">Sangsawat M</searchLink>; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Supaweera+N%22">Supaweera N</searchLink>; Health Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.<br /><searchLink fieldCode="AU" term="%22Chunglok+W%22">Chunglok W</searchLink>; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.; Food Technology and Innovation Center of Excellence, Research and Innovation Institute of Excellence, Walailak University, Nakhon Si Thammarat, 80160, Thailand.<br /><searchLink fieldCode="AU" term="%22Rahmadani+A%22">Rahmadani A</searchLink>; Department of Chemistry Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, 75123, East Kalimantan, Indonesia.<br /><searchLink fieldCode="AU" term="%22Ajavakom+V%22">Ajavakom V</searchLink>; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.<br /><searchLink fieldCode="AU" term="%22Rojsitthisak+P%22">Rojsitthisak P</searchLink>; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Suksamrarn+A%22">Suksamrarn A</searchLink>; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.
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  Data: <searchLink fieldCode="JN" term="%229211347%22">Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents</searchLink> [Med Chem Res] 2026 Mar; Vol. 35 (3), pp. 581-593. <i>Date of Electronic Publication: </i>2026 Jan 24.
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        Value: 10.1007/s00044-026-03528-3
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        Text: English
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              Text: 2026 Mar
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