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Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.

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Title: Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.
Authors: Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. ellen.souzacruz@uel.br., Concato-Lopes VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Gonçalves-Lens MD; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, Center of Exact Sciences, State University of Londrina, Londrina, PR, Brazil., de Souza MC, Inoue FSR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Nunes AP; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., da Silva Siqueira E; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Rodrigues ACJ; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Dos Santos-Destro YM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Santos NC; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., de Sousa Silva JM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., da Silva ÉI; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Providello MV; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Seiva FRF; Laboratory of Biochemistry and Experimental Morphology, Department of Chemistry and Biochemistry, São Paulo State University Júlio de Mesquita Filho, Institute of Biosciences of Botucatu, São Paulo, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. wanderpavanelli@uel.br.
Source: Archives of toxicology [Arch Toxicol] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Cruz+EMS%22">Cruz EMS</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. ellen.souzacruz@uel.br.<br /><searchLink fieldCode="AU" term="%22Concato-Lopes+VM%22">Concato-Lopes VM</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Detoni+MB%22">Detoni MB</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves-Lens+MD%22">Gonçalves-Lens MD</searchLink>; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, Center of Exact Sciences, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+MC%22">de Souza MC</searchLink><br /><searchLink fieldCode="AU" term="%22Inoue+FSR%22">Inoue FSR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Nunes+AP%22">Nunes AP</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Siqueira+E%22">da Silva Siqueira E</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+ACJ%22">Rodrigues ACJ</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos-Destro+YM%22">Dos Santos-Destro YM</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+NC%22">Santos NC</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Silva+JM%22">de Sousa Silva JM</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+ÉI%22">da Silva ÉI</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Providello+MV%22">Providello MV</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Lazarin-Bidóia+D%22">Lazarin-Bidóia D</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Seiva+FRF%22">Seiva FRF</searchLink>; Laboratory of Biochemistry and Experimental Morphology, Department of Chemistry and Biochemistry, São Paulo State University Júlio de Mesquita Filho, Institute of Biosciences of Botucatu, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pavanelli+WR%22">Pavanelli WR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. wanderpavanelli@uel.br.
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