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Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.

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Title: Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.
Authors: Vasu S; The Ohio State University Columbus, OH United States., Denlinger N; The Ohio State University United States., Song NJ; The Ohio State University Columbus, OH United States., Elsberry D; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio United States., Zhao Q; The Ohio State University Columbus United States., Yu L; The Ohio State University Columbus, OH United States., Bezerra ED; Mayo Clinic Rochester United States., Szuminski N; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States., Schneider D; Cartesian Therapeutics Frederick, Maryland United States., Dash P; Lentigen Technology (United States) Gaithersburg United States., Wirthlin L; Lentigen Technology (United States) Gaithersburg, MD United States., Epperla N; Huntsman Cancer Institute Salt Lake City, UT United States., Sawalha Y; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States., Woyach JA; The Ohio State University Comprehensive Cancer Center Columbus, Ohio United States., Nishat S; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States., Rogers KA; The Ohio State University Columbus, OH United States., Bhat SA; The Ohio State University Columbus, OH United States., Ghoneim HE; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio United States., Behbehani GK; The Ohio State University Columbus, OH United States., Voorhees TJ; University of North Carolina at Chapel Hill Columbus, Ohio United States., Larkin K; The Ohio State University Columbus, Ohio United States., Kittai AS; The Ohio State University Mineola, NY United States., Churchill V; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States., George E; Nationwide Children's Hospital Columbus, Ohio United States., Lamb M; Nationwide Children's Hospital Columbus, Ohio United States., Lee DA; Nationwide Children's Hospital Columbus, Ohio United States., Chan WK; The Ohio State University Columbus, OH United States., Krull A; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States., Orentas RJ; Lentigen Technology (United States) Gaithersburg, MD United States., O'Donnell L; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, OH United States., Li Z; The Ohio State University Columbus, OH United States., Alinari L; The Ohio State University Columbus, OH United States., de Lima M; The Ohio State University Columbus, OH United States.
Source: Blood cancer discovery [Blood Cancer Discov] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.
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  Data: <searchLink fieldCode="AU" term="%22Vasu+S%22">Vasu S</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Denlinger+N%22">Denlinger N</searchLink>; The Ohio State University United States.<br /><searchLink fieldCode="AU" term="%22Song+NJ%22">Song NJ</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Elsberry+D%22">Elsberry D</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; The Ohio State University Columbus United States.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Bezerra+ED%22">Bezerra ED</searchLink>; Mayo Clinic Rochester United States.<br /><searchLink fieldCode="AU" term="%22Szuminski+N%22">Szuminski N</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States.<br /><searchLink fieldCode="AU" term="%22Schneider+D%22">Schneider D</searchLink>; Cartesian Therapeutics Frederick, Maryland United States.<br /><searchLink fieldCode="AU" term="%22Dash+P%22">Dash P</searchLink>; Lentigen Technology (United States) Gaithersburg United States.<br /><searchLink fieldCode="AU" term="%22Wirthlin+L%22">Wirthlin L</searchLink>; Lentigen Technology (United States) Gaithersburg, MD United States.<br /><searchLink fieldCode="AU" term="%22Epperla+N%22">Epperla N</searchLink>; Huntsman Cancer Institute Salt Lake City, UT United States.<br /><searchLink fieldCode="AU" term="%22Sawalha+Y%22">Sawalha Y</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States.<br /><searchLink fieldCode="AU" term="%22Woyach+JA%22">Woyach JA</searchLink>; The Ohio State University Comprehensive Cancer Center Columbus, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Nishat+S%22">Nishat S</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States.<br /><searchLink fieldCode="AU" term="%22Rogers+KA%22">Rogers KA</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Bhat+SA%22">Bhat SA</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Ghoneim+HE%22">Ghoneim HE</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. 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Solove Research Institute United States.<br /><searchLink fieldCode="AU" term="%22George+E%22">George E</searchLink>; Nationwide Children's Hospital Columbus, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Lamb+M%22">Lamb M</searchLink>; Nationwide Children's Hospital Columbus, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Lee+DA%22">Lee DA</searchLink>; Nationwide Children's Hospital Columbus, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Chan+WK%22">Chan WK</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Krull+A%22">Krull A</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute United States.<br /><searchLink fieldCode="AU" term="%22Orentas+RJ%22">Orentas RJ</searchLink>; Lentigen Technology (United States) Gaithersburg, MD United States.<br /><searchLink fieldCode="AU" term="%22O'Donnell+L%22">O'Donnell L</searchLink>; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22Alinari+L%22">Alinari L</searchLink>; The Ohio State University Columbus, OH United States.<br /><searchLink fieldCode="AU" term="%22de+Lima+M%22">de Lima M</searchLink>; The Ohio State University Columbus, OH United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101764786 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2643-3249 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226433230%22">26433230 </searchLink><i>NLM ISO Abbreviation: </i>Blood Cancer Discov <i>Subsets: </i>MEDLINE
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        Value: 10.1158/2643-3230.BCD-26-0186
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