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Pemetrexed potentiates γδ T cell-based immunotherapy in NSCLC through ATM-STING-NF-κB-mediated induction of NKG2D ligands.

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Title: Pemetrexed potentiates γδ T cell-based immunotherapy in NSCLC through ATM-STING-NF-κB-mediated induction of NKG2D ligands.
Authors: Hung MY; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan., Lin H; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan; Master in Senior Health and Exercise Science, Tunghai University, Taichung, Taiwan., Li YH; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan., Cho DY; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan; Department of Neurosurgery, Neuropsychiatric Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Chiu SC; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Pan CM; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan., Huang SW; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan., Fang HY; Division of Thoracic Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan., Chen YW; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Kan KW; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen MC; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan. Electronic address: 033019@tool.caaumed.org.tw.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jul 14; Vol. 186, pp. 117115. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pemetrexed potentiates γδ T cell-based immunotherapy in NSCLC through ATM-STING-NF-κB-mediated induction of NKG2D ligands.
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  Data: <searchLink fieldCode="AU" term="%22Hung+MY%22">Hung MY</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan; Master in Senior Health and Exercise Science, Tunghai University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+YH%22">Li YH</searchLink>; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cho+DY%22">Cho DY</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan; Department of Neurosurgery, Neuropsychiatric Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+SC%22">Chiu SC</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Pan+CM%22">Pan CM</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SW%22">Huang SW</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Drug Development Center, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fang+HY%22">Fang HY</searchLink>; Division of Thoracic Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YW%22">Chen YW</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kan+KW%22">Kan KW</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+MC%22">Chen MC</searchLink>; Department of Medical Research, Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung, Taiwan. Electronic address: 033019@tool.caaumed.org.tw.
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  Data: <searchLink fieldCode="JN" term="%22100965259%22">International immunopharmacology</searchLink> [Int Immunopharmacol] 2026 Jul 14; Vol. 186, pp. 117115. <i>Date of Electronic Publication: </i>2026 Jul 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100965259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1705 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215675769%22">15675769 </searchLink><i>NLM ISO Abbreviation: </i>Int Immunopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.intimp.2026.117115
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              Text: 2026 Jul 14
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