CXCR4-EGFR heteromers show ligand-dependent changes in conformation and signaling.

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Title: CXCR4-EGFR heteromers show ligand-dependent changes in conformation and signaling.
Authors: Comez D; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK., Anbuhl SM; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands; QVQ, Universiteitsweg 101, 3584 CG Utrecht, the Netherlands., Platt S; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK., Isaac OC; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK., Karsai N; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK., Markus R; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK., Siderius M; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands., Smit MJ; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands., Heukers R; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands; QVQ, Universiteitsweg 101, 3584 CG Utrecht, the Netherlands., Kilpatrick LE; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK; Division of Bimolecular Science and Medicinal Chemistry, Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, UK., Hill SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK. Electronic address: steve.hill@nottingham.ac.uk.
Source: Cell chemical biology [Cell Chem Biol] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CXCR4-EGFR heteromers show ligand-dependent changes in conformation and signaling.
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  Data: <searchLink fieldCode="AU" term="%22Comez+D%22">Comez D</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Anbuhl+SM%22">Anbuhl SM</searchLink>; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands; QVQ, Universiteitsweg 101, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Platt+S%22">Platt S</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Isaac+OC%22">Isaac OC</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Karsai+N%22">Karsai N</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Markus+R%22">Markus R</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Siderius+M%22">Siderius M</searchLink>; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Smit+MJ%22">Smit MJ</searchLink>; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Heukers+R%22">Heukers R</searchLink>; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, the Netherlands; QVQ, Universiteitsweg 101, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kilpatrick+LE%22">Kilpatrick LE</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK; Division of Bimolecular Science and Medicinal Chemistry, Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Hill+SJ%22">Hill SJ</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, UK. Electronic address: steve.hill@nottingham.ac.uk.
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        Value: 10.1016/j.chembiol.2026.06.008
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      – TitleFull: CXCR4-EGFR heteromers show ligand-dependent changes in conformation and signaling.
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              Text: 2026 Jul 14
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