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Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.

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Title: Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.
Authors: Naderian M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Smith JL; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Dikilitas O; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; Mayo Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN, USA., Hamed ME; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Abul-Husn NS; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Connolly JJ; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Cortopassi JB; University of Alabama at Birmingham, Birmingham, AL, USA., Feng Q; Vanderbilt University Medical Center, Nashville, TN, USA., Hanks SC; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Irvin R; University of Alabama at Birmingham, Birmingham, AL, USA., Jarvik GP; University of Washington, Seattle, WA, USA., Kenny EE; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Khan A; Columbia University, New York, NY, USA., Kottyan LC; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Limdi NA; University of Alabama at Birmingham, Birmingham, AL, USA., McNally EM; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Miller E; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Namjou-Khales B; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA., Roy-Puckelwartz M; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Rowley R; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Tiwari HK; University of Alabama at Birmingham, Birmingham, AL, USA., Wei WQ; Vanderbilt University Medical Center, Nashville, TN, USA., Wiesner G; Vanderbilt University Medical Center, Nashville, TN, USA., Manolio TA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Sharp RR; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA., Kullo IJ; Division of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ikullo@mcw.edu.
Source: American journal of human genetics [Am J Hum Genet] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Naderian+M%22">Naderian M</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JL%22">Smith JL</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dikilitas+O%22">Dikilitas O</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; Mayo Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hamed+ME%22">Hamed ME</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Abul-Husn+NS%22">Abul-Husn NS</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Connolly+JJ%22">Connolly JJ</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cortopassi+JB%22">Cortopassi JB</searchLink>; University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Feng+Q%22">Feng Q</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hanks+SC%22">Hanks SC</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Irvin+R%22">Irvin R</searchLink>; University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Jarvik+GP%22">Jarvik GP</searchLink>; University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kenny+EE%22">Kenny EE</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kottyan+LC%22">Kottyan LC</searchLink>; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Limdi+NA%22">Limdi NA</searchLink>; University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22McNally+EM%22">McNally EM</searchLink>; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Miller+E%22">Miller E</searchLink>; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Namjou-Khales+B%22">Namjou-Khales B</searchLink>; Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Roy-Puckelwartz+M%22">Roy-Puckelwartz M</searchLink>; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rowley+R%22">Rowley R</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+HK%22">Tiwari HK</searchLink>; University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Wei+WQ%22">Wei WQ</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wiesner+G%22">Wiesner G</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Manolio+TA%22">Manolio TA</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+RR%22">Sharp RR</searchLink>; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kullo+IJ%22">Kullo IJ</searchLink>; Division of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ikullo@mcw.edu.
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        Value: 10.1016/j.ajhg.2026.06.014
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