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Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS-DLAT axis and promoting M2 macrophage polarization.

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Title: Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS-DLAT axis and promoting M2 macrophage polarization.
Authors: Yang YF; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Lin MH; Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Lin YY; Department of Biomedical Imagine and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chang PM; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan., Kim CH; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, SungKyunKwan University, Suwon, Gyunggi-Do, Republic of Korea., Chang YC; Department of Biomedical Imagine and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: yuchanchang@nycu.edu.tw., Tsai KW; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address: tch33225@tzuchi.com.tw.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Jul 14; Vol. 255, pp. 81-94. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS-DLAT axis and promoting M2 macrophage polarization.
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  Data: <searchLink fieldCode="AU" term="%22Yang+YF%22">Yang YF</searchLink>; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YY%22">Lin YY</searchLink>; Department of Biomedical Imagine and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+PM%22">Chang PM</searchLink>; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kim+CH%22">Kim CH</searchLink>; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, SungKyunKwan University, Suwon, Gyunggi-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chang+YC%22">Chang YC</searchLink>; Department of Biomedical Imagine and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: yuchanchang@nycu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Tsai+KW%22">Tsai KW</searchLink>; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address: tch33225@tzuchi.com.tw.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 Jul 14; Vol. 255, pp. 81-94. <i>Date of Electronic Publication: </i>2026 Jul 14.
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      – Type: doi
        Value: 10.1016/j.freeradbiomed.2026.07.026
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      – TitleFull: Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS-DLAT axis and promoting M2 macrophage polarization.
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              Text: 2026 Jul 14
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