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7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer's disease.

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Title: 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer's disease.
Authors: Radhakrishnan K; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.; Division of Endocrinology and Metabolism, University of Virginia, PO Box 801406, Charlottesville, VA, 22908, USA., Zhang Y; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA., Mustapha O; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA., Weigel TK; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA., Upchurch CM; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA., Tian X; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA., Herbert F; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA., Huang W; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA., Leitinger N; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA., Eyo UB; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA., Ai H; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA. huiwang.ai@virginia.edu.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA. huiwang.ai@virginia.edu., Ferris HA; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.; Division of Endocrinology and Metabolism, University of Virginia, PO Box 801406, Charlottesville, VA, 22908, USA. HF4F@uvahealth.org.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.
Source: Scientific reports [Sci Rep] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Radhakrishnan+K%22">Radhakrishnan K</searchLink>; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.; Division of Endocrinology and Metabolism, University of Virginia, PO Box 801406, Charlottesville, VA, 22908, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Mustapha+O%22">Mustapha O</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Weigel+TK%22">Weigel TK</searchLink>; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Upchurch+CM%22">Upchurch CM</searchLink>; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+F%22">Herbert F</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Leitinger+N%22">Leitinger N</searchLink>; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Eyo+UB%22">Eyo UB</searchLink>; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Ai+H%22">Ai H</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA, USA. huiwang.ai@virginia.edu.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA. huiwang.ai@virginia.edu.<br /><searchLink fieldCode="AU" term="%22Ferris+HA%22">Ferris HA</searchLink>; Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.; Division of Endocrinology and Metabolism, University of Virginia, PO Box 801406, Charlottesville, VA, 22908, USA. HF4F@uvahealth.org.; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA. HF4F@uvahealth.org.
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        Value: 10.1038/s41598-026-61753-7
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      – TitleFull: 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer's disease.
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              Text: 2026 Jul 14
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