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Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.

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Title: Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.
Authors: Qin T; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Bogle R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Jiang R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Sarkar MK; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Cai Y; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gharaee-Kermani M; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Fox J; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Xing X; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Marella S; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Nakamura M; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Maverakis E; PHYSIOSEQ, Sacramento, CA, USA.; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Le ST; PHYSIOSEQ, Sacramento, CA, USA., Merleev AA; PHYSIOSEQ, Sacramento, CA, USA., Marusina AI; PHYSIOSEQ, Sacramento, CA, USA., Simpson CL; Department of Dermatology, University of Washington, Seattle, WA, USA., Parihar A; Department of Dermatology, University of Washington, Seattle, WA, USA., Hill C; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Li H; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA., Waterworth DM; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Sabins N; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Miller LS; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Freeman TC; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Leung MW; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Polak ME; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Tsoi LC; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu., Billi AC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. acbilli@med.umich.edu., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bogle+R%22">Bogle R</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+R%22">Jiang R</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sarkar+MK%22">Sarkar MK</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gharaee-Kermani+M%22">Gharaee-Kermani M</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fox+J%22">Fox J</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xing+X%22">Xing X</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Marella+S%22">Marella S</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nakamura+M%22">Nakamura M</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Maverakis+E%22">Maverakis E</searchLink>; PHYSIOSEQ, Sacramento, CA, USA.; Department of Dermatology, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Le+ST%22">Le ST</searchLink>; PHYSIOSEQ, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Merleev+AA%22">Merleev AA</searchLink>; PHYSIOSEQ, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Marusina+AI%22">Marusina AI</searchLink>; PHYSIOSEQ, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Simpson+CL%22">Simpson CL</searchLink>; Department of Dermatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Parihar+A%22">Parihar A</searchLink>; Department of Dermatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hill+C%22">Hill C</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kahlenberg+JM%22">Kahlenberg JM</searchLink>; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Waterworth+DM%22">Waterworth DM</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sabins+N%22">Sabins N</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+LS%22">Miller LS</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+TC%22">Freeman TC</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Leung+MW%22">Leung MW</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Polak+ME%22">Polak ME</searchLink>; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tsoi+LC%22">Tsoi LC</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Billi+AC%22">Billi AC</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. acbilli@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Gudjonsson+JE%22">Gudjonsson JE</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.
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