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Blood biomarkers predict conversion from cognitively stable to mild cognitive impairment or Alzheimer's disease in Down syndrome at 16-month follow-up in ABC-DS.

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Title: Blood biomarkers predict conversion from cognitively stable to mild cognitive impairment or Alzheimer's disease in Down syndrome at 16-month follow-up in ABC-DS.
Authors: Zhang F; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA., Petersen M; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA., Mapstone M; Department of Neurology, University of California, Irvine, California, USA., Hall J; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Christian B; Department of Medical Physics and Psychiatry, University of Wisconsin Madison, Madison, Wisconsin, USA., Head E; Department of Pathology & Laboratory Medicine, Department of Neurology, University of California, Irvine, California, USA., Rosas HD; Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Lai F; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Lee JH; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.; Department of Neurology, Neurological Institute, Columbia University Irving Medical Center, New York, New York, USA., Krinsky-McHale SJ; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA., Schmitt FA; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA., Harp J; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA., Hom C; Department of Psychiatry & Human Behavior, University of California, Irvine, California, USA., Lott IT; Department of Pediatrics, University of California, Irvine, California, USA., Hartley S; Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK., Ances BM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Ptomey L; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Burns JM; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA., Cohen AD; Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Bryant SEO; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Corporate Authors: Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS) Investigators*
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jul; Vol. 22 (7), pp. e71659.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Blood biomarkers predict conversion from cognitively stable to mild cognitive impairment or Alzheimer's disease in Down syndrome at 16-month follow-up in ABC-DS.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+M%22">Petersen M</searchLink>; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hall+J%22">Hall J</searchLink>; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Handen+B%22">Handen B</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Christian+B%22">Christian B</searchLink>; Department of Medical Physics and Psychiatry, University of Wisconsin Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology & Laboratory Medicine, Department of Neurology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.; Department of Neurology, Neurological Institute, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+SJ%22">Krinsky-McHale SJ</searchLink>; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt+FA%22">Schmitt FA</searchLink>; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Harp+J%22">Harp J</searchLink>; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Hom+C%22">Hom C</searchLink>; Department of Psychiatry & Human Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hartley+S%22">Hartley S</searchLink>; Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Ptomey+L%22">Ptomey L</searchLink>; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Burns+JM%22">Burns JM</searchLink>; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AD%22">Cohen AD</searchLink>; Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Bryant+SEO%22">Bryant SEO</searchLink>; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
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