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Age predicts Alzheimer's in Down syndrome better than MRI, plasma, or cognition.

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Title: Age predicts Alzheimer's in Down syndrome better than MRI, plasma, or cognition.
Authors: Kennedy JT; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA., Wisch JK; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hartley S; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Human Development & Family Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA., Brickman AM; Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Lee JH; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University Irving Medical Center, New York, New York, USA., Krinsky-McHale S; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, USA., Lai F; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Rosas H; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Head E; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Department of Pathology, University of California, Irvine, California, USA., Christian B; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Zaman S; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge, UK., Lott IT; Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA., Hom C; Psychiatry & Human Behavior, University of California, Irvine, California, USA., Ptomey LT; Cardiovascular Research Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Burns JM; University of Kansas Alzheimer's Disease Center, Kansas City, Kansas, USA., Cohen A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Tudorascu D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Laymon C; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lao P; Department of Neurology, Columbia University, New York, New York, USA., Petersen M; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA., Schmitt F; Alzheimer's Disease Research Center, University of Kentucky, Lexington, Kentucky, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA., Ances BM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jul; Vol. 22 (7), pp. e71661.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: Age predicts Alzheimer's in Down syndrome better than MRI, plasma, or cognition.
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  Data: <searchLink fieldCode="AU" term="%22Kennedy+JT%22">Kennedy JT</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Wisch+JK%22">Wisch JK</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hartley+S%22">Hartley S</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Human Development & Family Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+S%22">Krinsky-McHale S</searchLink>; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+H%22">Rosas H</searchLink>; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Department of Pathology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Christian+B%22">Christian B</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hom+C%22">Hom C</searchLink>; Psychiatry & Human Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Ptomey+LT%22">Ptomey LT</searchLink>; Cardiovascular Research Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Burns+JM%22">Burns JM</searchLink>; University of Kansas Alzheimer's Disease Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+A%22">Cohen A</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+D%22">Tudorascu D</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Laymon+C%22">Laymon C</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lao+P%22">Lao P</searchLink>; Department of Neurology, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+M%22">Petersen M</searchLink>; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt+F%22">Schmitt F</searchLink>; Alzheimer's Disease Research Center, University of Kentucky, Lexington, Kentucky, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
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