Adjuvant therapy with total salvianolic acid injection enhances the safety and efficacy of recombinant prourokinase in ischemic stroke by mitigating blood-brain barrier disruption.

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Title: Adjuvant therapy with total salvianolic acid injection enhances the safety and efficacy of recombinant prourokinase in ischemic stroke by mitigating blood-brain barrier disruption.
Authors: Wang XY; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China.; China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing, China., Li Q; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China., Yan L; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China., Wang D; Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, China., Pan CS; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China., Fan JY; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China., Ma ZZ; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China. zhma@bjmu.edu.cn.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China. zhma@bjmu.edu.cn.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China. zhma@bjmu.edu.cn.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China. zhma@bjmu.edu.cn., Han JY; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China. hanjingyan@bjmu.edu.cn.; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China. hanjingyan@bjmu.edu.cn.; Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China. hanjingyan@bjmu.edu.cn.; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing, China. hanjingyan@bjmu.edu.cn.; State Key Laboratory of Core Technology in Innovative Chinese Medicine, Beijing, China. hanjingyan@bjmu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08583-3